TY - JOUR
T1 - The developing story of Sprouty and cancer
AU - Masoumi-Moghaddam, Samar
AU - Amini, Afshin
AU - Morris, David Lawson
PY - 2014
Y1 - 2014
N2 - Sprouty proteins are evolutionarily conserved modulators of MAPK/ERK pathway. Through interacting with an increasing number of effectors, mediators, and regulators with ultimate influence on multiple targets within or beyond ERK, Sprouty orchestrates a complex, multilayered regulatory system and mediates a crosstalk among different signaling pathways for a coordinated cellular response. As such, Sprouty has been implicated in various developmental and physiological processes. Evidence shows that ERK is aberrantly activated in malignant conditions. Accordingly, Sprouty deregulation has been reported in different cancer types and shown to impact cancer development, progression, and metastasis. In this article, we have tried to provide an overview of the current knowledge about the Sprouty physiology and its regulatory functions in health, as well as an updated review of the Sprouty status in cancer. Putative implications of Sprouty in cancer biology, their clinical relevance, and their proposed applications are also revisited. As a developing story, however, role of Sprouty in cancer remains to be further elucidated.
AB - Sprouty proteins are evolutionarily conserved modulators of MAPK/ERK pathway. Through interacting with an increasing number of effectors, mediators, and regulators with ultimate influence on multiple targets within or beyond ERK, Sprouty orchestrates a complex, multilayered regulatory system and mediates a crosstalk among different signaling pathways for a coordinated cellular response. As such, Sprouty has been implicated in various developmental and physiological processes. Evidence shows that ERK is aberrantly activated in malignant conditions. Accordingly, Sprouty deregulation has been reported in different cancer types and shown to impact cancer development, progression, and metastasis. In this article, we have tried to provide an overview of the current knowledge about the Sprouty physiology and its regulatory functions in health, as well as an updated review of the Sprouty status in cancer. Putative implications of Sprouty in cancer biology, their clinical relevance, and their proposed applications are also revisited. As a developing story, however, role of Sprouty in cancer remains to be further elucidated.
KW - Cancer
KW - Growth factors
KW - MAPK/ERK
KW - RTK
KW - Sprouty
UR - http://www.scopus.com/inward/record.url?scp=84905114377&partnerID=8YFLogxK
U2 - 10.1007/s10555-014-9497-1
DO - 10.1007/s10555-014-9497-1
M3 - Review Article
C2 - 24744103
AN - SCOPUS:84905114377
SN - 0167-7659
VL - 33
SP - 695
EP - 720
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
IS - 2-3
ER -