The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x)

Paul V. Murphy, Rod E. Hubbard, David T. Manallack, Ruth E. Wills, John G. Montana, Richard J.K. Taylor

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Abstract

The design and synthesis of a series of analogues of sialyl Lewis(x) (1) which incorporate conformationally rigid tetralin and naphthalene ring systems (2-4) has led to novel compounds which have similar potency to 1 as inhibitors of cell adhesion. Copyright (C) 1998 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2421-2439
Number of pages19
JournalBioorganic & Medicinal Chemistry
Volume6
Issue number12
DOIs
Publication statusPublished - 1 Jan 1998
Externally publishedYes

Keywords

  • Cell adhesion
  • Naphthalenes
  • Selectin inhibitors
  • Sialyl lewis(x)
  • Tetralins

Cite this

Murphy, P. V., Hubbard, R. E., Manallack, D. T., Wills, R. E., Montana, J. G., & Taylor, R. J. K. (1998). The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x). Bioorganic & Medicinal Chemistry, 6(12), 2421-2439. https://doi.org/10.1016/S0968-0896(98)80017-5