The design and synthesis of novel adenosine agonists

P. J. Scammells; S. P. Baker; L. Bellardinelli; L. Bellardinelli; R. A. Olsson; R. A. Russell; S. A. Knevitt

doi:10.1016/0960-894X(96)00111-4

The design and synthesis of novel adenosine agonists

P. J. Scammells, S. P. Baker, L. Bellardinelli, L. Bellardinelli, R. A. Olsson, R. A. Russell, S. A. Knevitt

Medicinal Chemistry

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

The 2R and 2S-endo isomers of N6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A1adenosine receptor. The 2S-endo isomer was equipotent to N6-cyclopentyladenosine and 10- to 12-fold more potent than the 2R-endo isomer.

Original language	English
Pages (from-to)	811-814
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	7
DOIs	https://doi.org/10.1016/0960-894X(96)00111-4
Publication status	Published - 9 Apr 1996

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title = "The design and synthesis of novel adenosine agonists",

abstract = "The 2R and 2S-endo isomers of N6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A1adenosine receptor. The 2S-endo isomer was equipotent to N6-cyclopentyladenosine and 10- to 12-fold more potent than the 2R-endo isomer.",

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AU - Scammells, P. J.

AU - Baker, S. P.

AU - Bellardinelli, L.

AU - Olsson, R. A.

AU - Russell, R. A.

AU - Knevitt, S. A.

PY - 1996/4/9

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N2 - The 2R and 2S-endo isomers of N6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A1adenosine receptor. The 2S-endo isomer was equipotent to N6-cyclopentyladenosine and 10- to 12-fold more potent than the 2R-endo isomer.

AB - The 2R and 2S-endo isomers of N6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A1adenosine receptor. The 2S-endo isomer was equipotent to N6-cyclopentyladenosine and 10- to 12-fold more potent than the 2R-endo isomer.

UR - https://www.scopus.com/pages/publications/0030005828

U2 - 10.1016/0960-894X(96)00111-4

DO - 10.1016/0960-894X(96)00111-4

M3 - Article

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VL - 6

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JO - Bioorganic and Medicinal Chemistry Letters

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The design and synthesis of novel adenosine agonists

Abstract

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