The design and synthesis of novel adenosine agonists

P. J. Scammells, S. P. Baker, L. Bellardinelli, L. Bellardinelli, R. A. Olsson, R. A. Russell, S. A. Knevitt

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


The 2R and 2S-endo isomers of N6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A1adenosine receptor. The 2S-endo isomer was equipotent to N6-cyclopentyladenosine and 10- to 12-fold more potent than the 2R-endo isomer.
Original languageEnglish
Pages (from-to)811-814
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number7
Publication statusPublished - 9 Apr 1996

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