The Curious Case of Avian Sex Determination

Craig A. Smith; Andrew T. Major; Martin A. Estermann

doi:10.1016/j.tig.2021.03.006

The Curious Case of Avian Sex Determination

Craig A. Smith, Andrew T. Major, Martin A. Estermann

Research output: Contribution to journal › Short Survey › Other › peer-review

6 Citations (Scopus)

Abstract

Ioannidis and colleagues show that the gene DMRT1 is the master regulator of testis development in the chicken. Yet, remarkably, when this gene is deleted in genetic males and gonads form ovaries, the body remains male. This debunks the notion that somatic sex is driven primarily by hormones in birds.

Original language	English
Pages (from-to)	496-497
Number of pages	2
Journal	Trends in Genetics
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/j.tig.2021.03.006
Publication status	Published - Jun 2021

Keywords

avian sex
chicken embryo
DMRT1
gonad
gonadal sex differentiation
sex determination

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10.1016/j.tig.2021.03.006

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title = "The Curious Case of Avian Sex Determination",

abstract = "Ioannidis and colleagues show that the gene DMRT1 is the master regulator of testis development in the chicken. Yet, remarkably, when this gene is deleted in genetic males and gonads form ovaries, the body remains male. This debunks the notion that somatic sex is driven primarily by hormones in birds.",

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author = "Smith, {Craig A.} and Major, {Andrew T.} and Estermann, {Martin A.}",

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AU - Smith, Craig A.

AU - Major, Andrew T.

AU - Estermann, Martin A.

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N2 - Ioannidis and colleagues show that the gene DMRT1 is the master regulator of testis development in the chicken. Yet, remarkably, when this gene is deleted in genetic males and gonads form ovaries, the body remains male. This debunks the notion that somatic sex is driven primarily by hormones in birds.

AB - Ioannidis and colleagues show that the gene DMRT1 is the master regulator of testis development in the chicken. Yet, remarkably, when this gene is deleted in genetic males and gonads form ovaries, the body remains male. This debunks the notion that somatic sex is driven primarily by hormones in birds.

KW - avian sex

KW - chicken embryo

KW - DMRT1

KW - gonad

KW - gonadal sex differentiation

KW - sex determination

UR - http://www.scopus.com/inward/record.url?scp=85103954792&partnerID=8YFLogxK

U2 - 10.1016/j.tig.2021.03.006

DO - 10.1016/j.tig.2021.03.006

M3 - Short Survey

C2 - 33838938

AN - SCOPUS:85103954792

SN - 0168-9525

VL - 37

SP - 496

EP - 497

JO - Trends in Genetics

JF - Trends in Genetics

IS - 6

ER -

The Curious Case of Avian Sex Determination

Abstract

Keywords

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