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Numerous neuroimaging studies have shown that older adults tend to activate the brain to a greater extent than younger adults during the performance of a task. This is typically interpreted as evidence for cognitive compensation. The Compensation-Related Utilisation of Neural Circuits Hypothesis (CRUNCH) model is a highly influential model of compensation, and states that increased functional magnetic resonance imaging (fMRI) activity in older adults compared to younger adults should reverse at higher levels of task difficulty. Here, the CRUNCH model was tested using a visuospatial working memory paradigm. fMRI activity in older vs. younger adults was in the opposite direction to that predicted by the model. Given that the CRUNCH model is the predominant model of compensation, this result was surprising. These results were followed up with a systematic review of the CRUNCH in healthy ageing literature. A surprisingly small number of published studies (4) have tested the predictions of the CRUNCH model. Further experimental work is required to validate the CRUNCH model in cognitive ageing.
|Number of pages||11|
|Publication status||Published - May 2020|
- Cognitive ageing
- CRUNCH model
- Systematic review
1/01/20 → 31/12/24
Egan, G., Rosa, M., Lowery, A., Stuart, G., Arabzadeh, E., Skafidas, E., Ibbotson, M., Petrou, S., Paxinos, G., Mattingley, J., Garrido, M., Sah, P., Robinson, P. A., Martin, P., Grunert, U., Tanaka, K., Mitra, P., Johnson, G., Diamond, M., Margrie, T., Leopold, D., Movshon, J., Markram, H., Victor, J., Hill, S. & Jirsa, V.
Australian National University , ETH Zurich, Australian Research Council (ARC), Karolinska Institute, QIMR Berghofer Medical Research Institute, Ecole Polytechnique Federale de Lausanne , Monash University, University of Melbourne, University of New South Wales, University of Queensland , University of Sydney, Monash University – Internal University Contribution, National Institutes of Health (United States), Cornell University, New York University, MRC National Institute for Medical Research, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Duke University, Cold Spring Harbor Laboratory, RIKEN
25/06/14 → 31/12/21