Projects per year
Abstract
Numerous neuroimaging studies have shown that older adults tend to activate the brain to a greater extent than younger adults during the performance of a task. This is typically interpreted as evidence for cognitive compensation. The Compensation-Related Utilisation of Neural Circuits Hypothesis (CRUNCH) model is a highly influential model of compensation, and states that increased functional magnetic resonance imaging (fMRI) activity in older adults compared to younger adults should reverse at higher levels of task difficulty. Here, the CRUNCH model was tested using a visuospatial working memory paradigm. fMRI activity in older vs. younger adults was in the opposite direction to that predicted by the model. Given that the CRUNCH model is the predominant model of compensation, this result was surprising. These results were followed up with a systematic review of the CRUNCH in healthy ageing literature. A surprisingly small number of published studies (4) have tested the predictions of the CRUNCH model. Further experimental work is required to validate the CRUNCH model in cognitive ageing.
Original language | English |
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Article number | 107446 |
Number of pages | 11 |
Journal | Neuropsychologia |
Volume | 142 |
DOIs | |
Publication status | Published - May 2020 |
Keywords
- Cognitive ageing
- Compensation
- CRUNCH model
- Reproducibility
- Systematic review
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Neural metabolic connectivity in ageing and neurodegeneration
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/24
Project: Research
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Cognitive Compensation in Ageing
Australian Research Council (ARC)
9/03/15 → 15/03/20
Project: Research
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ARC Centre of Excellence for Integrative Brain Function
Egan, G., Rosa, M., Lowery, A., Stuart, G., Arabzadeh, E., Skafidas, E., Ibbotson, M., Petrou, S., Paxinos, G., Mattingley, J., Garrido, M., Sah, P., Robinson, P. A., Martin, P., Grunert, U., Tanaka, K., Mitra, P., Johnson, G., Diamond, M., Margrie, T., Leopold, D., Movshon, J., Markram, H., Victor, J., Hill, S. & Jirsa, V.
Australian National University (ANU), ETH Zurich, Australian Research Council (ARC), Karolinska Institute, QIMR Berghofer Medical Research Institute, Ecole Polytechnique Federale de Lausanne (EPFL) (Swiss Federal Institute of Technology in Lausanne) , Monash University, University of Melbourne, University of New South Wales (UNSW), University of Queensland , University of Sydney, Monash University – Internal University Contribution, National Institutes of Health (United States), Cornell University, New York University, MRC National Institute for Medical Research, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Duke University, Cold Spring Harbor Laboratory, RIKEN
25/06/14 → 31/12/21
Project: Research
Equipment
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Biomedical Imaging (MBI)
Gary Egan (Manager) & Kylie Reid (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility