The course of uveitis in pregnancy and postpartum

Nathalie P Y Chiam, Anthony J H Hall, Richard J. Stawell, Lucy Busija, Lyndell L P Lim

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Aim: To examine the course of non-infectious uveitis during pregnancy. Methods: This is a retrospective case series. The medical records of 47 subjects with a previous history of non-infectious uveitis pre-dating their pregnancy were reviewed. Uveitis activity during the periods 1 year before pregnancy, during pregnancy and 1 year postpartum, were recorded. Information on patient demographics, type of uveitis, medication use, sex of child and breastfeeding status were also collected. The main outcome measures were the events of flare-ups during the prepregnancy, pregnancy and postpartum periods. Results: The rate of flare-up was 1.188 per person year prior to pregnancy, 0.540 per person year during pregnancy and 0.972 per person year in postpartum (p<0.001 for comparison between prepregnancy and pregnancy; p=0.009 for comparison between pregnancy and postpartum). Rates of flare-up only began to decrease in the second trimester. After delivery, rates of flare-up rebounded and within 6 months postpartum, flare-up rates were not significantly different from prepregnancy levels (p=0.306). Even so, 40% of subjects were found to have remained inactive within 1 year postpartum. Conclusions: Uveitis activity decreased by midpregnancy, but returned to prepregnancy levels within 6 months postpartum. These findings may be used to adjust uveitis management during pregnancy and the postpartum period.

Original languageEnglish
Pages (from-to)1284-1288
Number of pages5
JournalBritish Journal of Ophthalmology
Volume97
Issue number10
DOIs
Publication statusPublished - Oct 2013
Externally publishedYes

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