The correlation between central corneal thickness and glaucomatous optic nerve damage in a human eye

Chai Yee Loke, Ean Hin Ooi, Norlina Ramli, Amir Samsudin

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

1 Citation (Scopus)

Abstract

Results from clinical studies suggest a strong correlation between central corneal thickness (CCT) and glaucomatous optic nerve damage. A 3D model is developed to carry out structural investigation of the IOP-induced posterior displacement of the lamina cribrosa (LC), under the influence of CCT. The cornea, the sclera and the LC are assumed to exhibit nonlinear material properties. The numerical results suggest a higher glaucoma progression rate with a lower CCT, which supports the clinical trend. The low influential rate of CCT towards optic nerve damage suggests that CCT may not be a dominant factor in structural injury of the nerve bundles. The results indicate that CCT measurement can be significant in the diagnostic system of glaucoma.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering, WC 2018
PublisherSpringer
Pages655-660
Number of pages6
Volume68
Edition1
DOIs
Publication statusPublished - 2019
EventWorld Congress on Medical Physics and Biomedical Engineering 2018 - Prague, Czechia
Duration: 3 Jun 20188 Jun 2018
https://link.springer.com/book/10.1007/978-981-10-9035-6 (Proceedings)

Publication series

NameIFMBE Proceedings
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering 2018
Abbreviated titleWC 2018
Country/TerritoryCzechia
CityPrague
Period3/06/188/06/18
Internet address

Keywords

  • Central corneal thickness
  • Glaucoma
  • Optic nerve damage

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