The conundrum of the gut microbiome and blood pressure: The importance of studying sex and ethnicity

Rikeish R. Muralitharan, Michael E. Nakai, Francine Z. Marques

Research output: Contribution to journalEditorialOtherpeer-review

1 Citation (Scopus)

Abstract

Blood pressure (BP) has proven to be one of the most challenging phenotypes in terms of untangling its contributing factors. The largest genome-wide association study to date in >1 million participants identified 901 loci that together could explain only 5.7% of interindividual systolic BP variance.1 This has led to the recent proposal that the other genome in our body, the gut microbiome, could hold some of the missing origins of hypertension.2 This is plausible as hypertension and the gut microbiota share many modulating factors, including diet, but testing this hypothesis requires cohorts with sizeable statistical power.
Original languageEnglish
Pages (from-to)4268-4270
Number of pages3
JournalEuropean Heart Journal
Volume41
Issue number44
DOIs
Publication statusPublished - 21 Nov 2020

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