TY - JOUR
T1 - The contribution of Mycoplasma genitalium to the aetiology of sexually acquired infectious proctitis in men who have sex with men
AU - Bissessor, Melanie
AU - Tabrizi, Sepehr N
AU - Bradshaw, Catriona
AU - Fairley, Christopher Kit
AU - Hocking, Jane Simone
AU - Garland, Suzanne
AU - Twin, Jimmy
AU - Poljak, Marin
AU - Peel, Joanne
AU - Chen, Marcus Y
PY - 2016
Y1 - 2016
N2 - This study examined the contribution of Mycoplasma genitalium to sexually acquired infectious proctitis in men who have sex with men (MSM). MSM with symptomatic proctitis between May 2012 and August 2013 were tested for rectal sexually transmitted infections including chlamydia, gonorrhoea, herpes simplex virus (HSV) and M. genitalium. The load of rectal M. genitalium in men with symptomatic proctitis was compared with a separate group of men who had rectal M. genitalium but no symptoms of proctitis. Among 154 MSM with proctitis, rectal M. genitalium was detected in 18 men (12%, 95% CI 6.9–17.1) and was significantly more common among human immunodeficiency virus (HIV) -positive men (21%, 95% CI 9.5–32.6) than HIV-negative men (8%, 95% CI 2.9–13.1; prevalence ratio 3.2, 95% CI 1.2–8.8). Among HIV-positive men the detection of M. genitalium was comparable to that for chlamydia (21%, 95% CI 9.5–32.5), gonorrhoea (25%, 95% CI 16.2–41.8) and HSV (19%, 95% CI 7.9–30.1). Rectal M. genitalium load was significantly higher among the 18 men with symptomatic M. genitalium-associated proctitis than among a separate group of 18 men with asymptomatic rectal M. genitalium infection (60 000 copies of organism/swab versus 10 744 copies of organism/swab, p 0.023). Comprehensive testing for rectal pathogens in MSM with proctitis should include testing for M. genitalium.
AB - This study examined the contribution of Mycoplasma genitalium to sexually acquired infectious proctitis in men who have sex with men (MSM). MSM with symptomatic proctitis between May 2012 and August 2013 were tested for rectal sexually transmitted infections including chlamydia, gonorrhoea, herpes simplex virus (HSV) and M. genitalium. The load of rectal M. genitalium in men with symptomatic proctitis was compared with a separate group of men who had rectal M. genitalium but no symptoms of proctitis. Among 154 MSM with proctitis, rectal M. genitalium was detected in 18 men (12%, 95% CI 6.9–17.1) and was significantly more common among human immunodeficiency virus (HIV) -positive men (21%, 95% CI 9.5–32.6) than HIV-negative men (8%, 95% CI 2.9–13.1; prevalence ratio 3.2, 95% CI 1.2–8.8). Among HIV-positive men the detection of M. genitalium was comparable to that for chlamydia (21%, 95% CI 9.5–32.5), gonorrhoea (25%, 95% CI 16.2–41.8) and HSV (19%, 95% CI 7.9–30.1). Rectal M. genitalium load was significantly higher among the 18 men with symptomatic M. genitalium-associated proctitis than among a separate group of 18 men with asymptomatic rectal M. genitalium infection (60 000 copies of organism/swab versus 10 744 copies of organism/swab, p 0.023). Comprehensive testing for rectal pathogens in MSM with proctitis should include testing for M. genitalium.
KW - Human immunodeficiency virus
KW - Men who have sex with men
KW - Mycoplasma genitalium
KW - Proctitis
KW - Sexually transmitted infections
UR - http://www.sciencedirect.com/science/article/pii/S1198743X15010228
U2 - 10.1016/j.cmi.2015.11.016
DO - 10.1016/j.cmi.2015.11.016
M3 - Article
SN - 1198-743X
VL - 22
SP - 260
EP - 265
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 3
ER -