The contribution of cone responses to rat electroretinograms

Peter J Nixon, Bang V Bui, James Armitage, Algis Vingrys

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Abstract

The contribution of rods and cones to the scotopic electroretinogram (ERG) of small animals is unclear, with a recent report suggesting that the mouse has no cone a-wave. The present study considered the contribution of cones to the ERG of the rat. Dark-adapted Long Evans rats (n = 4) had ERG signals collected following a single flash, which stimulated rods and cones (mixed response), or a twin-fash paradigm (short interstimulus interval, 1 s), which isolated cone responses. Rod signals were derived by digital subtraction of the cone signal from the mixed rod/cone ERG. The rat a-wave was found to be dominated by rod responses but cone responses contributed substantially (45 ) to post-receptoral waveforms (b-wave) at higher light levels.
Original languageEnglish
Pages (from-to)193 - 196
Number of pages4
JournalClinical and Experimental Ophthalmology
Volume29
Issue number3
Publication statusPublished - 2001

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