The complexity of signalling mediated by the glucagon-like peptide-1 receptor

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

The glucagon-like peptide-1 receptor (GLP-1R) is a class B GPCR that is a major therapeutic target for the treatment of type 2 diabetes. The receptor is activated by the incretin peptide GLP-1 promoting a broad range of physiological effects including glucose-dependent insulin secretion and biosynthesis, improved insulin sensitivity of peripheral tissues, preservation of β-cell mass and weight loss, all of which are beneficial in the treatment of type 2 diabetes. Despite this, existing knowledge surrounding the underlying signalling mechanisms responsible for the physiological actions downstream of GLP-1R activation is limited. Here, we review the current understanding around GLP-1R-mediated signalling, in particular highlighting recent contributions to the field on biased agonism, the spatial and temporal aspects for the control of signalling and how these concepts may influence future drug development.

Original languageEnglish
Pages (from-to)582-588
Number of pages7
JournalBiochemical Society Transactions
Volume44
Issue number2
DOIs
Publication statusPublished - 15 Apr 2016

Keywords

  • Biased signalling
  • G protein-coupled receptor
  • Glucagon-like peptide-1 receptor
  • Ligand-directed signalling bias

Cite this