The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing

Lucy C. Sullivan, Evangeline M. Shaw, Sanda Stankovic, Gregory I. Snell, Andrew G. Brooks, Glen P. Westall

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes is under-researched. γδ T cells can recognise a diverse array of ligands and exert disparate effector functions. As such, they may potentially contribute to both allograft acceptance and rejection, as well as impacting on infection and post-transplant malignancy. Here, we review the current literature on the role and function of γδ T cells following solid organ and hematopoietic stem cell transplantation.

Original languageEnglish
Article numbere1078
Number of pages10
JournalClinical & Translational Immunology
Volume8
Issue number9
DOIs
Publication statusPublished - Jan 2019
Externally publishedYes

Keywords

  • gamma delta T cells
  • graft-versus-host disease
  • transplant immunology

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