Abstract
BACKGROUND: Panadol Extend (PEx) is an over-the-counter, modified-release formulation of paracetamol. Each 665 mg tablet contains 69 slow-release and 31 immediate-release paracetamol. In simulated human overdose, PEx exhibits lower and later peak serum concentrations and a lower area-under-the-curve (AUC) than comparable doses of immediate-release paracetamol (APAP-IR). The lower AUC might result from incomplete absorption of paracetamol or simultaneous metabolism with absorption.
OBJECTIVE: Do differences in pharmacokinetics (PK) between PEx and APAP-IR result from incomplete absorption or simultaneous absorption and metabolism of paracetamol?
Original language | English |
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Pages (from-to) | 548 - 555 |
Number of pages | 8 |
Journal | EMA - Emergency Medicine Australasia |
Volume | 22 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2010 |