The comparative pharmacokinetics of modified-release and immediate-release paracetamol in a simulated overdose model

Angela Chiew, Peter Day, Chris Salonikas, Daya Naidoo, Andis Graudins, Rebecca Thomas

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

BACKGROUND: Panadol Extend (PEx) is an over-the-counter, modified-release formulation of paracetamol. Each 665 mg tablet contains 69 slow-release and 31 immediate-release paracetamol. In simulated human overdose, PEx exhibits lower and later peak serum concentrations and a lower area-under-the-curve (AUC) than comparable doses of immediate-release paracetamol (APAP-IR). The lower AUC might result from incomplete absorption of paracetamol or simultaneous metabolism with absorption. OBJECTIVE: Do differences in pharmacokinetics (PK) between PEx and APAP-IR result from incomplete absorption or simultaneous absorption and metabolism of paracetamol?
Original languageEnglish
Pages (from-to)548 - 555
Number of pages8
JournalEMA - Emergency Medicine Australasia
Volume22
Issue number6
DOIs
Publication statusPublished - 2010

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