The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model

Zakuan Zainy Deris, Heidi Yu, Kathryn Erin Davis, Rachel Li-Xia Soon, Jovan Jacob, Ka Uen Caron Ku, Anima Poudyal, Phillip John Bergen, Brian Tsuji, Jurgen Bernd Bulitta, Alan Forrest, David L Paterson, Tony Velkov, Jian Li, Roger Leigh Nation

Research output: Contribution to journal › Article › Research › peer-review

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Optimizing dosing of colistin for infections resistant to all other antibiotics.
Nation, R. & Li, J.
NIH - National Institutes of Health (United States of America)
15/09/08 → 31/08/12
Project: Research
Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.
Nation, R., Li, J., Forrest, A., Paterson, D. L. & Tsuji, B. T.
NIH - National Institutes of Health (United States of America)
15/07/08 → 30/06/12
Project: Research

The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model

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Optimizing dosing of colistin for infections resistant to all other antibiotics.

Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.