The ChemoArchiChip: Interrogating the response of macrophages to the chemistry and geometry of microscale 3D objects

Jessica E. Frith

doi:10.1016/j.matt.2023.02.004

The ChemoArchiChip: Interrogating the response of macrophages to the chemistry and geometry of microscale 3D objects

Jessica E. Frith

Materials Science & Engineering

Research output: Contribution to journal › Comment / Debate › Other › peer-review

Abstract

Effective integration of biomedical implants requires understanding and control of interactions between cells and the implant surface. High-throughput screening and modeling can identify properties that elicit desired cell behaviors and reveal patterns to underpin the future development of general design rules. Recently in Matter, Vassey et al. developed the ChemoArchiChip to investigate effects of microscale 3D objects with varied material chemistry on the adhesion and polarization of macrophages. The study shows the power of screening and modeling to generate understanding of cell-biomaterial interactions and provides specific knowledge of conditions to modulate the macrophage response.

Original language	English
Pages (from-to)	1058-1060
Number of pages	3
Journal	Matter
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.matt.2023.02.004
Publication status	Published - 5 Apr 2023

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10.1016/j.matt.2023.02.004

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title = "The ChemoArchiChip: Interrogating the response of macrophages to the chemistry and geometry of microscale 3D objects",

abstract = "Effective integration of biomedical implants requires understanding and control of interactions between cells and the implant surface. High-throughput screening and modeling can identify properties that elicit desired cell behaviors and reveal patterns to underpin the future development of general design rules. Recently in Matter, Vassey et al. developed the ChemoArchiChip to investigate effects of microscale 3D objects with varied material chemistry on the adhesion and polarization of macrophages. The study shows the power of screening and modeling to generate understanding of cell-biomaterial interactions and provides specific knowledge of conditions to modulate the macrophage response.",

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note = "Funding Information: The author is a co-inventor on patent application PCT/AU2022/050,282 “Hot embossing method for imparting micro- and nano-topographies on thermoplastic polymer surfaces, including cultureware.” Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

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N1 - Funding Information: The author is a co-inventor on patent application PCT/AU2022/050,282 “Hot embossing method for imparting micro- and nano-topographies on thermoplastic polymer surfaces, including cultureware.” Publisher Copyright: © 2023 Elsevier Inc.

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N2 - Effective integration of biomedical implants requires understanding and control of interactions between cells and the implant surface. High-throughput screening and modeling can identify properties that elicit desired cell behaviors and reveal patterns to underpin the future development of general design rules. Recently in Matter, Vassey et al. developed the ChemoArchiChip to investigate effects of microscale 3D objects with varied material chemistry on the adhesion and polarization of macrophages. The study shows the power of screening and modeling to generate understanding of cell-biomaterial interactions and provides specific knowledge of conditions to modulate the macrophage response.

AB - Effective integration of biomedical implants requires understanding and control of interactions between cells and the implant surface. High-throughput screening and modeling can identify properties that elicit desired cell behaviors and reveal patterns to underpin the future development of general design rules. Recently in Matter, Vassey et al. developed the ChemoArchiChip to investigate effects of microscale 3D objects with varied material chemistry on the adhesion and polarization of macrophages. The study shows the power of screening and modeling to generate understanding of cell-biomaterial interactions and provides specific knowledge of conditions to modulate the macrophage response.

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SN - 2590-2393

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SP - 1058

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JO - Matter

JF - Matter

IS - 4

ER -

The ChemoArchiChip: Interrogating the response of macrophages to the chemistry and geometry of microscale 3D objects

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