The central nervous system and inflammation in hypertension

Paul J. Marvar, Heinrich Emil Lob, Antony Vinh, Faresa Zarreen, David G. Harrison

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Abstract

In recent years a major research effort has focused on the role of inflammation, and in particular adaptive immunity, in the genesis of hypertension. Hypertension stimulates the accumulation of inflammatory cells including macrophages and T lymphocytes in peripheral tissues important in blood pressure control, such as the kidney and vasculature. Angiotensin II modulates blood pressure via actions on the central nervous system (CNS) and the adaptive immune system. Recent work suggests that the central actions of angiotensin II via the circumventricular organs lead to activation of circulating T-cells and vascular inflammation. The neuro-immune system plays an essential role in the pathogenesis of hypertension and further understanding of this relationship could lead to the development of new treatment strategies.

Original languageEnglish
Pages (from-to)156-161
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume11
Issue number2
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

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