The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers

Kim San Tang

doi:10.1016/j.lfs.2019.116695

The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers

Kim San Tang

Malaysia Sch of Pharmacy

Research output: Contribution to journal › Review Article › Other › peer-review

120 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model in studying cognitive disorders including AD. Many studies have also concurrently examined the neurochemical mechanisms underlying the behavioral modifications by scopolamine treatment. Nonetheless, the scopolamine model has not become a standard tool in the early assessment of drugs. Furthermore, the use of scopolamine as a pharmacological model to study AD remains debatable. This report reviews the scopolamine-induced cellular and molecular changes and discusses how these changes relate to AD pathogenesis.

Original language	English
Article number	116695
Number of pages	6
Journal	Life Sciences
Volume	233
DOIs	https://doi.org/10.1016/j.lfs.2019.116695
Publication status	Published - 15 Sept 2019

Keywords

Alzheimer's disease
Amyloid beta-peptides
Apoptosis
Dementia
Inflammation
Oxidative stress
Scopolamine
Tau proteins

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title = "The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers",

abstract = "Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model in studying cognitive disorders including AD. Many studies have also concurrently examined the neurochemical mechanisms underlying the behavioral modifications by scopolamine treatment. Nonetheless, the scopolamine model has not become a standard tool in the early assessment of drugs. Furthermore, the use of scopolamine as a pharmacological model to study AD remains debatable. This report reviews the scopolamine-induced cellular and molecular changes and discusses how these changes relate to AD pathogenesis.",

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N1 - Funding Information: This work was supported by the Ministry of Education, Malaysia (project code: FRGS/1/2012/SKK01/MUSM/03/1 ). Publisher Copyright: © 2019 Elsevier Inc. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

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N2 - Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model in studying cognitive disorders including AD. Many studies have also concurrently examined the neurochemical mechanisms underlying the behavioral modifications by scopolamine treatment. Nonetheless, the scopolamine model has not become a standard tool in the early assessment of drugs. Furthermore, the use of scopolamine as a pharmacological model to study AD remains debatable. This report reviews the scopolamine-induced cellular and molecular changes and discusses how these changes relate to AD pathogenesis.

AB - Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model in studying cognitive disorders including AD. Many studies have also concurrently examined the neurochemical mechanisms underlying the behavioral modifications by scopolamine treatment. Nonetheless, the scopolamine model has not become a standard tool in the early assessment of drugs. Furthermore, the use of scopolamine as a pharmacological model to study AD remains debatable. This report reviews the scopolamine-induced cellular and molecular changes and discusses how these changes relate to AD pathogenesis.

KW - Alzheimer's disease

KW - Amyloid beta-peptides

KW - Apoptosis

KW - Dementia

KW - Inflammation

KW - Oxidative stress

KW - Scopolamine

KW - Tau proteins

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DO - 10.1016/j.lfs.2019.116695

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JO - Life Sciences

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The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers

Abstract

Keywords

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