The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep

D Burrage, L Green, Timothy Moss, Deborah M Sloboda, Ilias Nitsos, John Newnham, M Hanson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

OBJECTIVE: To determine the role of carotid sinus innervation on differential fetal organ growth during maternal nutrient restriction in late pregnancy. DESIGN: Randomised controlled study. SETTING: University research facility. SAMPLE: Thirty-nine Merino ewes. METHODS: At 113 days gestational age (dGA), fetuses were bilaterally carotid sinus denervated or sham denervated. From 118 dGA, the surgery groups were subdivided into two dietary groups, and their ewes were fed 100 of nutrient requirements or 50 until tissue collection at 140 dGA. This provided four groups (sham/control diet, sham/restricted diet, denervated/control diet and denervated/restricted diet). MAIN OUTCOME MEASURES: Fetal organ weights and hormone levels and maternal weight change during the dietary restriction. RESULTS: Adrenal glands were larger in sham/restricted diet fetuses than in sham/control diet or denervated/restricted diet fetuses (P <0.05). Fetal adrenal weight and brain-to-liver weight ratio were positively related to maternal weight change during the nutritional challenge in sham fetuses only (P <0.05). Fetal liver weight was negatively related to maternal weight change during nutritional challenge in sham fetuses only (P <0.05). CONCLUSIONS: We have shown a reduction in liver growth but sparing of adrenal growth in response to moderate maternal undernutrition, which is dependent on intact carotid body innervation. This suggests a new role for the carotid bodies in the control of differential organ growth during such undernutrition.
Original languageEnglish
Pages (from-to)261 - 268
Number of pages8
JournalBJOG: an International Journal of Obstetrics and Gynaecology
Volume115
Issue number2
DOIs
Publication statusPublished - 2008
Externally publishedYes

Cite this

Burrage, D ; Green, L ; Moss, Timothy ; Sloboda, Deborah M ; Nitsos, Ilias ; Newnham, John ; Hanson, M. / The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep. In: BJOG: an International Journal of Obstetrics and Gynaecology. 2008 ; Vol. 115, No. 2. pp. 261 - 268.
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abstract = "OBJECTIVE: To determine the role of carotid sinus innervation on differential fetal organ growth during maternal nutrient restriction in late pregnancy. DESIGN: Randomised controlled study. SETTING: University research facility. SAMPLE: Thirty-nine Merino ewes. METHODS: At 113 days gestational age (dGA), fetuses were bilaterally carotid sinus denervated or sham denervated. From 118 dGA, the surgery groups were subdivided into two dietary groups, and their ewes were fed 100 of nutrient requirements or 50 until tissue collection at 140 dGA. This provided four groups (sham/control diet, sham/restricted diet, denervated/control diet and denervated/restricted diet). MAIN OUTCOME MEASURES: Fetal organ weights and hormone levels and maternal weight change during the dietary restriction. RESULTS: Adrenal glands were larger in sham/restricted diet fetuses than in sham/control diet or denervated/restricted diet fetuses (P <0.05). Fetal adrenal weight and brain-to-liver weight ratio were positively related to maternal weight change during the nutritional challenge in sham fetuses only (P <0.05). Fetal liver weight was negatively related to maternal weight change during nutritional challenge in sham fetuses only (P <0.05). CONCLUSIONS: We have shown a reduction in liver growth but sparing of adrenal growth in response to moderate maternal undernutrition, which is dependent on intact carotid body innervation. This suggests a new role for the carotid bodies in the control of differential organ growth during such undernutrition.",
author = "D Burrage and L Green and Timothy Moss and Sloboda, {Deborah M} and Ilias Nitsos and John Newnham and M Hanson",
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The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep. / Burrage, D; Green, L; Moss, Timothy; Sloboda, Deborah M; Nitsos, Ilias; Newnham, John; Hanson, M.

In: BJOG: an International Journal of Obstetrics and Gynaecology, Vol. 115, No. 2, 2008, p. 261 - 268.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep

AU - Burrage, D

AU - Green, L

AU - Moss, Timothy

AU - Sloboda, Deborah M

AU - Nitsos, Ilias

AU - Newnham, John

AU - Hanson, M

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: To determine the role of carotid sinus innervation on differential fetal organ growth during maternal nutrient restriction in late pregnancy. DESIGN: Randomised controlled study. SETTING: University research facility. SAMPLE: Thirty-nine Merino ewes. METHODS: At 113 days gestational age (dGA), fetuses were bilaterally carotid sinus denervated or sham denervated. From 118 dGA, the surgery groups were subdivided into two dietary groups, and their ewes were fed 100 of nutrient requirements or 50 until tissue collection at 140 dGA. This provided four groups (sham/control diet, sham/restricted diet, denervated/control diet and denervated/restricted diet). MAIN OUTCOME MEASURES: Fetal organ weights and hormone levels and maternal weight change during the dietary restriction. RESULTS: Adrenal glands were larger in sham/restricted diet fetuses than in sham/control diet or denervated/restricted diet fetuses (P <0.05). Fetal adrenal weight and brain-to-liver weight ratio were positively related to maternal weight change during the nutritional challenge in sham fetuses only (P <0.05). Fetal liver weight was negatively related to maternal weight change during nutritional challenge in sham fetuses only (P <0.05). CONCLUSIONS: We have shown a reduction in liver growth but sparing of adrenal growth in response to moderate maternal undernutrition, which is dependent on intact carotid body innervation. This suggests a new role for the carotid bodies in the control of differential organ growth during such undernutrition.

AB - OBJECTIVE: To determine the role of carotid sinus innervation on differential fetal organ growth during maternal nutrient restriction in late pregnancy. DESIGN: Randomised controlled study. SETTING: University research facility. SAMPLE: Thirty-nine Merino ewes. METHODS: At 113 days gestational age (dGA), fetuses were bilaterally carotid sinus denervated or sham denervated. From 118 dGA, the surgery groups were subdivided into two dietary groups, and their ewes were fed 100 of nutrient requirements or 50 until tissue collection at 140 dGA. This provided four groups (sham/control diet, sham/restricted diet, denervated/control diet and denervated/restricted diet). MAIN OUTCOME MEASURES: Fetal organ weights and hormone levels and maternal weight change during the dietary restriction. RESULTS: Adrenal glands were larger in sham/restricted diet fetuses than in sham/control diet or denervated/restricted diet fetuses (P <0.05). Fetal adrenal weight and brain-to-liver weight ratio were positively related to maternal weight change during the nutritional challenge in sham fetuses only (P <0.05). Fetal liver weight was negatively related to maternal weight change during nutritional challenge in sham fetuses only (P <0.05). CONCLUSIONS: We have shown a reduction in liver growth but sparing of adrenal growth in response to moderate maternal undernutrition, which is dependent on intact carotid body innervation. This suggests a new role for the carotid bodies in the control of differential organ growth during such undernutrition.

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DO - 10.1111/j.1471-0528.2007.01607.x

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EP - 268

JO - BJOG: an International Journal of Obstetrics and Gynaecology

JF - BJOG: an International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 2

ER -