The cardiopulmonary haemodynamic transition at birth is not different between male and female preterm lambs

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Males born preterm are at greater risk of illness and death than females, principally due to respiratory disease. Much of the excess morbidity occurs within the first few hours of life. Therefore, the aim of the present study was to investigate whether or not differences in the cardiopulmonary transition soon after birth underlie the increased morbidity in males after preterm birth. Nine female and thirteen male lambs (128+/-2 days gestation) underwent surgery immediately before delivery for implantation of a pulmonary arterial flow-probe and catheters into the main pulmonary artery and a carotid artery. After birth lambs were ventilated for 30 min (tidal volume 7 mL kg(-1)) while anaesthetised. Arterial pressures and flows were recorded in real time and left-ventricular output measured using Doppler echocardiography. Before birth, fetal cardiopulmonary haemodynamics, arterial blood gases, pH, glucose and lactate did not differ between sexes. Similarly, in the neonatal period there were no significant differences in arterial blood gas status, ventilation parameters, respiratory indices or cardiopulmonary haemodynamics between the sexes. Our data show that the cardiopulmonary transition at birth in ventilated, anaesthetised preterm lambs is not influenced by sex. Thus, the neonatal male disadvantage is not explained by an impaired cardiovascular transition at birth.
Original languageEnglish
Pages (from-to)510 - 516
Number of pages7
JournalReproduction, Fertility and Development
Volume24
Issue number3
DOIs
Publication statusPublished - 2012

Cite this

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title = "The cardiopulmonary haemodynamic transition at birth is not different between male and female preterm lambs",
abstract = "Males born preterm are at greater risk of illness and death than females, principally due to respiratory disease. Much of the excess morbidity occurs within the first few hours of life. Therefore, the aim of the present study was to investigate whether or not differences in the cardiopulmonary transition soon after birth underlie the increased morbidity in males after preterm birth. Nine female and thirteen male lambs (128+/-2 days gestation) underwent surgery immediately before delivery for implantation of a pulmonary arterial flow-probe and catheters into the main pulmonary artery and a carotid artery. After birth lambs were ventilated for 30 min (tidal volume 7 mL kg(-1)) while anaesthetised. Arterial pressures and flows were recorded in real time and left-ventricular output measured using Doppler echocardiography. Before birth, fetal cardiopulmonary haemodynamics, arterial blood gases, pH, glucose and lactate did not differ between sexes. Similarly, in the neonatal period there were no significant differences in arterial blood gas status, ventilation parameters, respiratory indices or cardiopulmonary haemodynamics between the sexes. Our data show that the cardiopulmonary transition at birth in ventilated, anaesthetised preterm lambs is not influenced by sex. Thus, the neonatal male disadvantage is not explained by an impaired cardiovascular transition at birth.",
author = "Graeme Polglase and Stuart Hooper and Martin Kluckow and Andrew Gill and Richard Harding and Timothy Moss",
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doi = "10.1071/RD11121",
language = "English",
volume = "24",
pages = "510 -- 516",
journal = "Reproduction, Fertility and Development",
issn = "1031-3613",
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The cardiopulmonary haemodynamic transition at birth is not different between male and female preterm lambs. / Polglase, Graeme; Hooper, Stuart; Kluckow, Martin; Gill, Andrew; Harding, Richard; Moss, Timothy.

In: Reproduction, Fertility and Development, Vol. 24, No. 3, 2012, p. 510 - 516.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The cardiopulmonary haemodynamic transition at birth is not different between male and female preterm lambs

AU - Polglase, Graeme

AU - Hooper, Stuart

AU - Kluckow, Martin

AU - Gill, Andrew

AU - Harding, Richard

AU - Moss, Timothy

PY - 2012

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AB - Males born preterm are at greater risk of illness and death than females, principally due to respiratory disease. Much of the excess morbidity occurs within the first few hours of life. Therefore, the aim of the present study was to investigate whether or not differences in the cardiopulmonary transition soon after birth underlie the increased morbidity in males after preterm birth. Nine female and thirteen male lambs (128+/-2 days gestation) underwent surgery immediately before delivery for implantation of a pulmonary arterial flow-probe and catheters into the main pulmonary artery and a carotid artery. After birth lambs were ventilated for 30 min (tidal volume 7 mL kg(-1)) while anaesthetised. Arterial pressures and flows were recorded in real time and left-ventricular output measured using Doppler echocardiography. Before birth, fetal cardiopulmonary haemodynamics, arterial blood gases, pH, glucose and lactate did not differ between sexes. Similarly, in the neonatal period there were no significant differences in arterial blood gas status, ventilation parameters, respiratory indices or cardiopulmonary haemodynamics between the sexes. Our data show that the cardiopulmonary transition at birth in ventilated, anaesthetised preterm lambs is not influenced by sex. Thus, the neonatal male disadvantage is not explained by an impaired cardiovascular transition at birth.

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