The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy

Kim Connelly; Andrew Advani; Sandra Kim; Suzanne Advani; Michael Zhang; Kathryn White; Young Kim; Colleen Parker; Kerri Thai; Henry Krum; Darren Kelly; Richard Gilbert

doi:10.1097/HJH.0b013e3283462674

The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy

Kim Connelly
, Andrew Advani
, Sandra Kim
, Suzanne Advani
, Michael Zhang
, Kathryn White
, Young Kim
, Colleen Parker
, Kerri Thai
, Henry Krum
, Darren Kelly
, Richard Gilbert

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

38 Citations (Scopus)

Abstract

Background: The pro(renin) receptor is a 350 amino acid transmembrane protein, that on ligand binding, increases the catalytic efficiency of angiotensinogen cleavage by both prorenin and renin, augmenting angiotensin I formation at the cell surface. While implicated in a broad range of diseases, studies to date have focused on the kidney, particularly in the diabetic context. We sought to examine the site-specific expression of the pro(renin) receptor within the heart.

Original language	English
Pages (from-to)	1175 - 1184
Number of pages	10
Journal	Journal of Hypertension
Volume	29
Issue number	6
DOIs	https://doi.org/10.1097/HJH.0b013e3283462674
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1097/HJH.0b013e3283462674

Cite this

Connelly, K., Advani, A., Kim, S., Advani, S., Zhang, M., White, K., Kim, Y., Parker, C., Thai, K., Krum, H., Kelly, D., & Gilbert, R. (2011). The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy. Journal of Hypertension, 29(6), 1175 - 1184. https://doi.org/10.1097/HJH.0b013e3283462674

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title = "The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy",

abstract = "Background: The pro(renin) receptor is a 350 amino acid transmembrane protein, that on ligand binding, increases the catalytic efficiency of angiotensinogen cleavage by both prorenin and renin, augmenting angiotensin I formation at the cell surface. While implicated in a broad range of diseases, studies to date have focused on the kidney, particularly in the diabetic context. We sought to examine the site-specific expression of the pro(renin) receptor within the heart.",

author = "Kim Connelly and Andrew Advani and Sandra Kim and Suzanne Advani and Michael Zhang and Kathryn White and Young Kim and Colleen Parker and Kerri Thai and Henry Krum and Darren Kelly and Richard Gilbert",

year = "2011",

doi = "10.1097/HJH.0b013e3283462674",

language = "English",

volume = "29",

pages = "1175 -- 1184",

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Connelly, K, Advani, A, Kim, S, Advani, S, Zhang, M, White, K, Kim, Y, Parker, C, Thai, K, Krum, H, Kelly, D & Gilbert, R 2011, 'The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy', Journal of Hypertension, vol. 29, no. 6, pp. 1175 - 1184. https://doi.org/10.1097/HJH.0b013e3283462674

TY - JOUR

T1 - The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy

AU - Connelly, Kim

AU - Advani, Andrew

AU - Kim, Sandra

AU - Advani, Suzanne

AU - Zhang, Michael

AU - White, Kathryn

AU - Kim, Young

AU - Parker, Colleen

AU - Thai, Kerri

AU - Krum, Henry

AU - Kelly, Darren

AU - Gilbert, Richard

PY - 2011

Y1 - 2011

N2 - Background: The pro(renin) receptor is a 350 amino acid transmembrane protein, that on ligand binding, increases the catalytic efficiency of angiotensinogen cleavage by both prorenin and renin, augmenting angiotensin I formation at the cell surface. While implicated in a broad range of diseases, studies to date have focused on the kidney, particularly in the diabetic context. We sought to examine the site-specific expression of the pro(renin) receptor within the heart.

AB - Background: The pro(renin) receptor is a 350 amino acid transmembrane protein, that on ligand binding, increases the catalytic efficiency of angiotensinogen cleavage by both prorenin and renin, augmenting angiotensin I formation at the cell surface. While implicated in a broad range of diseases, studies to date have focused on the kidney, particularly in the diabetic context. We sought to examine the site-specific expression of the pro(renin) receptor within the heart.

UR - http://www.ncbi.nlm.nih.gov/pubmed/21505358

U2 - 10.1097/HJH.0b013e3283462674

DO - 10.1097/HJH.0b013e3283462674

M3 - Article

SN - 0263-6352

VL - 29

SP - 1175

EP - 1184

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 6

ER -

The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy

Abstract

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