The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy

Kim Connelly, Andrew Advani, Sandra Kim, Suzanne Advani, Michael Zhang, Kathryn White, Young Kim, Colleen Parker, Kerri Thai, Henry Krum, Darren Kelly, Richard Gilbert

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

Background: The pro(renin) receptor is a 350 amino acid transmembrane protein, that on ligand binding, increases the catalytic efficiency of angiotensinogen cleavage by both prorenin and renin, augmenting angiotensin I formation at the cell surface. While implicated in a broad range of diseases, studies to date have focused on the kidney, particularly in the diabetic context. We sought to examine the site-specific expression of the pro(renin) receptor within the heart.
Original languageEnglish
Pages (from-to)1175 - 1184
Number of pages10
JournalJournal of Hypertension
Volume29
Issue number6
DOIs
Publication statusPublished - 2011

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