Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1-15 |
| Number of pages | 15 |
| Journal | Archives of Medical Research |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2018 |
Keywords
- myeloma
- Wnt signaling pathway
- therapetic target
Cite this
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The Canonical Wnt/β-catenin Pathway as a Therapeutic Target in Multiple Myeloma. / Savvidou, Ioanna; Khong, Tiffany; Spencer, Andrew; Alt, Karen Maria.
In: Archives of Medical Research, Vol. 6, No. 7, 07.2018, p. 1-15.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - The Canonical Wnt/β-catenin Pathway as a Therapeutic Target in Multiple Myeloma
AU - Savvidou, Ioanna
AU - Khong, Tiffany
AU - Spencer, Andrew
AU - Alt, Karen Maria
PY - 2018/7
Y1 - 2018/7
N2 - It has been more than 30 years since Nusse and Varmus identified a new mouse protooncogene int1 (integration 1), conserved across multiple species, and already recognised in Drosophila as Wingless (Wg). Wnts are now known to activate multiple signalling pathways, the best understood and extensively investigated being the canonical/β-catenin dependent pathway. β-catenin signalling has been found dysregulated to varying degrees and via multiple mechanisms in both solid and haematologic cancers, including multiple myeloma (MM). Recently developed inhibitors of the Wnt canonical pathway have proven to be potentially effective against MM, with minimal side effects. There is cautious optimism that some of these inhibitors will be added in our armamentarium against MM in the not so distant future. In this review, we discuss the possible mechanisms of Wnt-canonical pathway dysregulation in the pathogenesis of MM. Furthermore, we summarise the pathway inhibitors that have been validated in the disease in pre-clinical models or clinical trials and their potential challenges.
AB - It has been more than 30 years since Nusse and Varmus identified a new mouse protooncogene int1 (integration 1), conserved across multiple species, and already recognised in Drosophila as Wingless (Wg). Wnts are now known to activate multiple signalling pathways, the best understood and extensively investigated being the canonical/β-catenin dependent pathway. β-catenin signalling has been found dysregulated to varying degrees and via multiple mechanisms in both solid and haematologic cancers, including multiple myeloma (MM). Recently developed inhibitors of the Wnt canonical pathway have proven to be potentially effective against MM, with minimal side effects. There is cautious optimism that some of these inhibitors will be added in our armamentarium against MM in the not so distant future. In this review, we discuss the possible mechanisms of Wnt-canonical pathway dysregulation in the pathogenesis of MM. Furthermore, we summarise the pathway inhibitors that have been validated in the disease in pre-clinical models or clinical trials and their potential challenges.
KW - myeloma
KW - Wnt signaling pathway
KW - therapetic target
U2 - 10.18103/mra.v6i7.1821
DO - 10.18103/mra.v6i7.1821
M3 - Review Article
VL - 6
SP - 1
EP - 15
JO - Archives of Medical Research
JF - Archives of Medical Research
SN - 0188-4409
IS - 7
ER -