The burden of lung cancer mortality attributable to fine particles in China

Yuming Guo, Hongmei Zeng, Rongshou Zheng, Shanshan Li, Gavin Pereira, Qiyong Liu, Wanqing Chen, Rachel Huxley

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Abstract

Although studies have examined the associations between fine particles (PM2.5) and lung cancer mortality in US and European countries, the evidence is still limited for China. In addition, no study has provided estimates of spatial variation in lung cancer mortality attributable to PM2.5 in China. In this study, we quantified the associations between lung cancer mortality and PM2.5, using a spatiotemporal model with observed data of lung cancer mortality from 75 communities from the National Cancer Registration of China from 1990 to 2009 and the annual concentrations of PM2.5 at 0.5° × 0.5° spatial resolution. We also estimated lung cancer mortality burden attributable to PM2.5 in China, with predicted county level lung cancer deaths in 2005. We found that the PM2.5-lung cancer mortality associations were non-linear, with thresholds of 40 μg/m3 overall, 45 μg/m3 for male, 42 μg/m3 for female, 45 μg/m3 for those aged 30–64 years, 48 μg/m3 for those aged 65–74 years, and 40 μg/m3 for those aged 75 years and more, above which the relative risks were 1.08 (95% CI: 1.07, 1.09), 1.07 (95% CI: 1.05, 1.08), 1.12 (95% CI: 1.1, 1.14), 1.05 (95% CI: 1.04, 1.07), 1.07 (95% CI: 1.06, 1.09), and 1.14 (95% CI: 1.12, 1.16) respectively. There were 51,219 (95% CI: 45,745–56,512) lung cancer deaths attributed to PM2.5 in 2005, with attributable fractions of 13.7% (95% CI: 12.23–15.11%) overall, 10.01% (95% CI: 8.37–11.58%) for men, 18.06% (95% CI: 15.81–20.18%) for women, 8.35% (95% CI: 6.07–10.51%) for those aged 65–74 years, 9.73% (95% CI: 7.6–11.75%) for those aged 65–74 years, 21.7% (95% CI: 19.27–23.99%) for those aged 75 years or more. In conclusion, assuming a causal relation a reduction in exposure levels of PM2.5 below thresholds would avert a substantial number of deaths from lung cancer in China.

Original languageEnglish
Pages (from-to)1460-1466
Number of pages7
JournalScience of the Total Environment
Volume579
DOIs
Publication statusPublished - 1 Feb 2017
Externally publishedYes

Keywords

  • Air pollution
  • Attributable fraction
  • Attributable risk
  • Fine particles
  • Lung cancer mortality
  • Spatial age-period-cohort study

Cite this

Guo, Yuming ; Zeng, Hongmei ; Zheng, Rongshou ; Li, Shanshan ; Pereira, Gavin ; Liu, Qiyong ; Chen, Wanqing ; Huxley, Rachel. / The burden of lung cancer mortality attributable to fine particles in China. In: Science of the Total Environment. 2017 ; Vol. 579. pp. 1460-1466.
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title = "The burden of lung cancer mortality attributable to fine particles in China",
abstract = "Although studies have examined the associations between fine particles (PM2.5) and lung cancer mortality in US and European countries, the evidence is still limited for China. In addition, no study has provided estimates of spatial variation in lung cancer mortality attributable to PM2.5 in China. In this study, we quantified the associations between lung cancer mortality and PM2.5, using a spatiotemporal model with observed data of lung cancer mortality from 75 communities from the National Cancer Registration of China from 1990 to 2009 and the annual concentrations of PM2.5 at 0.5° × 0.5° spatial resolution. We also estimated lung cancer mortality burden attributable to PM2.5 in China, with predicted county level lung cancer deaths in 2005. We found that the PM2.5-lung cancer mortality associations were non-linear, with thresholds of 40 μg/m3 overall, 45 μg/m3 for male, 42 μg/m3 for female, 45 μg/m3 for those aged 30–64 years, 48 μg/m3 for those aged 65–74 years, and 40 μg/m3 for those aged 75 years and more, above which the relative risks were 1.08 (95{\%} CI: 1.07, 1.09), 1.07 (95{\%} CI: 1.05, 1.08), 1.12 (95{\%} CI: 1.1, 1.14), 1.05 (95{\%} CI: 1.04, 1.07), 1.07 (95{\%} CI: 1.06, 1.09), and 1.14 (95{\%} CI: 1.12, 1.16) respectively. There were 51,219 (95{\%} CI: 45,745–56,512) lung cancer deaths attributed to PM2.5 in 2005, with attributable fractions of 13.7{\%} (95{\%} CI: 12.23–15.11{\%}) overall, 10.01{\%} (95{\%} CI: 8.37–11.58{\%}) for men, 18.06{\%} (95{\%} CI: 15.81–20.18{\%}) for women, 8.35{\%} (95{\%} CI: 6.07–10.51{\%}) for those aged 65–74 years, 9.73{\%} (95{\%} CI: 7.6–11.75{\%}) for those aged 65–74 years, 21.7{\%} (95{\%} CI: 19.27–23.99{\%}) for those aged 75 years or more. In conclusion, assuming a causal relation a reduction in exposure levels of PM2.5 below thresholds would avert a substantial number of deaths from lung cancer in China.",
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The burden of lung cancer mortality attributable to fine particles in China. / Guo, Yuming; Zeng, Hongmei; Zheng, Rongshou; Li, Shanshan; Pereira, Gavin; Liu, Qiyong; Chen, Wanqing; Huxley, Rachel.

In: Science of the Total Environment, Vol. 579, 01.02.2017, p. 1460-1466.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The burden of lung cancer mortality attributable to fine particles in China

AU - Guo, Yuming

AU - Zeng, Hongmei

AU - Zheng, Rongshou

AU - Li, Shanshan

AU - Pereira, Gavin

AU - Liu, Qiyong

AU - Chen, Wanqing

AU - Huxley, Rachel

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N2 - Although studies have examined the associations between fine particles (PM2.5) and lung cancer mortality in US and European countries, the evidence is still limited for China. In addition, no study has provided estimates of spatial variation in lung cancer mortality attributable to PM2.5 in China. In this study, we quantified the associations between lung cancer mortality and PM2.5, using a spatiotemporal model with observed data of lung cancer mortality from 75 communities from the National Cancer Registration of China from 1990 to 2009 and the annual concentrations of PM2.5 at 0.5° × 0.5° spatial resolution. We also estimated lung cancer mortality burden attributable to PM2.5 in China, with predicted county level lung cancer deaths in 2005. We found that the PM2.5-lung cancer mortality associations were non-linear, with thresholds of 40 μg/m3 overall, 45 μg/m3 for male, 42 μg/m3 for female, 45 μg/m3 for those aged 30–64 years, 48 μg/m3 for those aged 65–74 years, and 40 μg/m3 for those aged 75 years and more, above which the relative risks were 1.08 (95% CI: 1.07, 1.09), 1.07 (95% CI: 1.05, 1.08), 1.12 (95% CI: 1.1, 1.14), 1.05 (95% CI: 1.04, 1.07), 1.07 (95% CI: 1.06, 1.09), and 1.14 (95% CI: 1.12, 1.16) respectively. There were 51,219 (95% CI: 45,745–56,512) lung cancer deaths attributed to PM2.5 in 2005, with attributable fractions of 13.7% (95% CI: 12.23–15.11%) overall, 10.01% (95% CI: 8.37–11.58%) for men, 18.06% (95% CI: 15.81–20.18%) for women, 8.35% (95% CI: 6.07–10.51%) for those aged 65–74 years, 9.73% (95% CI: 7.6–11.75%) for those aged 65–74 years, 21.7% (95% CI: 19.27–23.99%) for those aged 75 years or more. In conclusion, assuming a causal relation a reduction in exposure levels of PM2.5 below thresholds would avert a substantial number of deaths from lung cancer in China.

AB - Although studies have examined the associations between fine particles (PM2.5) and lung cancer mortality in US and European countries, the evidence is still limited for China. In addition, no study has provided estimates of spatial variation in lung cancer mortality attributable to PM2.5 in China. In this study, we quantified the associations between lung cancer mortality and PM2.5, using a spatiotemporal model with observed data of lung cancer mortality from 75 communities from the National Cancer Registration of China from 1990 to 2009 and the annual concentrations of PM2.5 at 0.5° × 0.5° spatial resolution. We also estimated lung cancer mortality burden attributable to PM2.5 in China, with predicted county level lung cancer deaths in 2005. We found that the PM2.5-lung cancer mortality associations were non-linear, with thresholds of 40 μg/m3 overall, 45 μg/m3 for male, 42 μg/m3 for female, 45 μg/m3 for those aged 30–64 years, 48 μg/m3 for those aged 65–74 years, and 40 μg/m3 for those aged 75 years and more, above which the relative risks were 1.08 (95% CI: 1.07, 1.09), 1.07 (95% CI: 1.05, 1.08), 1.12 (95% CI: 1.1, 1.14), 1.05 (95% CI: 1.04, 1.07), 1.07 (95% CI: 1.06, 1.09), and 1.14 (95% CI: 1.12, 1.16) respectively. There were 51,219 (95% CI: 45,745–56,512) lung cancer deaths attributed to PM2.5 in 2005, with attributable fractions of 13.7% (95% CI: 12.23–15.11%) overall, 10.01% (95% CI: 8.37–11.58%) for men, 18.06% (95% CI: 15.81–20.18%) for women, 8.35% (95% CI: 6.07–10.51%) for those aged 65–74 years, 9.73% (95% CI: 7.6–11.75%) for those aged 65–74 years, 21.7% (95% CI: 19.27–23.99%) for those aged 75 years or more. In conclusion, assuming a causal relation a reduction in exposure levels of PM2.5 below thresholds would avert a substantial number of deaths from lung cancer in China.

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KW - Attributable fraction

KW - Attributable risk

KW - Fine particles

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