The burden of invasive infections in critically ill indigenous children in Australia

Justyna A. Ostrowski, Graeme MacLaren, Janet Alexander, Penny Stewart, Sheena Gune, Joshua R. Francis, Subodh Ganu, Marino Festa, Simon J. Erickson, Lahn Straney, Luregn J Schlapbach

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10 Citations (Scopus)

Abstract

Objectives: To describe the incidence and mortality of invasive infections in Indigenous children admitted to paediatric and general intensive care units (ICUs) in Australia. Design: Retrospective multi-centre cohort study of Australian and New Zealand Paediatric Intensive Care Registry data. Participants: All children under 16 years of age admitted to an ICU in Australia, 1 January 2002 e 31 December 2013. Indigenous children were defined as those identified as Aboriginal and/or Torres Strait Islander in a mandatory admissions dataset. Main outcomes: Population-based ICU mortality and admission rates. Results: Invasive infections accounted for 23.0% of non-elective ICU admissions of Indigenous children (726 of 3150), resulting in an admission rate of 47.6 per 100 000 children per year. Staphylococcus aureus was the leading pathogen identified in children with sepsis/septic shock (incidence, 4.42 per 100 000 Indigenous children per year; 0.57 per 100 000 non-Indigenous children per year; incidence rate ratio 7.7; 95% CI, 5.8-10.1; P < 0.001). While crude and risk-adjusted ICU mortality related to invasive infections was not significantly different for Indigenous and non-Indigenous children (odds ratio, 0.75; 95% CI, 0.53-1.07; P = 0.12), the estimated population-based age-standardised mortality rate for invasive infections was significantly higher for Indigenous children (2.67 per 100 000 per year v 1.04 per 100 000 per year; crude incidence rate ratio, 2.65; 95% CI, 1.88e3.64; P < 0.001). Conclusions: The ICU admission rate for severe infections was several times higher for Indigenous than for non-Indigenous children, particularly for S. aureus infections. While ICU case fatality rates were similar, the population-based mortality was more than twice as high for Indigenous children. Our study highlights an important area of inequality in health care for Indigenous children in a high income country that needs urgent attention.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalMedical Journal of Australia
Volume206
Issue number2
DOIs
Publication statusPublished - 2017

Cite this

Ostrowski, J. A., MacLaren, G., Alexander, J., Stewart, P., Gune, S., Francis, J. R., ... Schlapbach, L. J. (2017). The burden of invasive infections in critically ill indigenous children in Australia. Medical Journal of Australia, 206(2), 78-84. https://doi.org/10.5694/mja16.00595
Ostrowski, Justyna A. ; MacLaren, Graeme ; Alexander, Janet ; Stewart, Penny ; Gune, Sheena ; Francis, Joshua R. ; Ganu, Subodh ; Festa, Marino ; Erickson, Simon J. ; Straney, Lahn ; Schlapbach, Luregn J. / The burden of invasive infections in critically ill indigenous children in Australia. In: Medical Journal of Australia. 2017 ; Vol. 206, No. 2. pp. 78-84.
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title = "The burden of invasive infections in critically ill indigenous children in Australia",
abstract = "Objectives: To describe the incidence and mortality of invasive infections in Indigenous children admitted to paediatric and general intensive care units (ICUs) in Australia. Design: Retrospective multi-centre cohort study of Australian and New Zealand Paediatric Intensive Care Registry data. Participants: All children under 16 years of age admitted to an ICU in Australia, 1 January 2002 e 31 December 2013. Indigenous children were defined as those identified as Aboriginal and/or Torres Strait Islander in a mandatory admissions dataset. Main outcomes: Population-based ICU mortality and admission rates. Results: Invasive infections accounted for 23.0{\%} of non-elective ICU admissions of Indigenous children (726 of 3150), resulting in an admission rate of 47.6 per 100 000 children per year. Staphylococcus aureus was the leading pathogen identified in children with sepsis/septic shock (incidence, 4.42 per 100 000 Indigenous children per year; 0.57 per 100 000 non-Indigenous children per year; incidence rate ratio 7.7; 95{\%} CI, 5.8-10.1; P < 0.001). While crude and risk-adjusted ICU mortality related to invasive infections was not significantly different for Indigenous and non-Indigenous children (odds ratio, 0.75; 95{\%} CI, 0.53-1.07; P = 0.12), the estimated population-based age-standardised mortality rate for invasive infections was significantly higher for Indigenous children (2.67 per 100 000 per year v 1.04 per 100 000 per year; crude incidence rate ratio, 2.65; 95{\%} CI, 1.88e3.64; P < 0.001). Conclusions: The ICU admission rate for severe infections was several times higher for Indigenous than for non-Indigenous children, particularly for S. aureus infections. While ICU case fatality rates were similar, the population-based mortality was more than twice as high for Indigenous children. Our study highlights an important area of inequality in health care for Indigenous children in a high income country that needs urgent attention.",
author = "Ostrowski, {Justyna A.} and Graeme MacLaren and Janet Alexander and Penny Stewart and Sheena Gune and Francis, {Joshua R.} and Subodh Ganu and Marino Festa and Erickson, {Simon J.} and Lahn Straney and Schlapbach, {Luregn J}",
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Ostrowski, JA, MacLaren, G, Alexander, J, Stewart, P, Gune, S, Francis, JR, Ganu, S, Festa, M, Erickson, SJ, Straney, L & Schlapbach, LJ 2017, 'The burden of invasive infections in critically ill indigenous children in Australia', Medical Journal of Australia, vol. 206, no. 2, pp. 78-84. https://doi.org/10.5694/mja16.00595

The burden of invasive infections in critically ill indigenous children in Australia. / Ostrowski, Justyna A.; MacLaren, Graeme; Alexander, Janet; Stewart, Penny; Gune, Sheena; Francis, Joshua R.; Ganu, Subodh; Festa, Marino; Erickson, Simon J.; Straney, Lahn; Schlapbach, Luregn J.

In: Medical Journal of Australia, Vol. 206, No. 2, 2017, p. 78-84.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The burden of invasive infections in critically ill indigenous children in Australia

AU - Ostrowski, Justyna A.

AU - MacLaren, Graeme

AU - Alexander, Janet

AU - Stewart, Penny

AU - Gune, Sheena

AU - Francis, Joshua R.

AU - Ganu, Subodh

AU - Festa, Marino

AU - Erickson, Simon J.

AU - Straney, Lahn

AU - Schlapbach, Luregn J

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N2 - Objectives: To describe the incidence and mortality of invasive infections in Indigenous children admitted to paediatric and general intensive care units (ICUs) in Australia. Design: Retrospective multi-centre cohort study of Australian and New Zealand Paediatric Intensive Care Registry data. Participants: All children under 16 years of age admitted to an ICU in Australia, 1 January 2002 e 31 December 2013. Indigenous children were defined as those identified as Aboriginal and/or Torres Strait Islander in a mandatory admissions dataset. Main outcomes: Population-based ICU mortality and admission rates. Results: Invasive infections accounted for 23.0% of non-elective ICU admissions of Indigenous children (726 of 3150), resulting in an admission rate of 47.6 per 100 000 children per year. Staphylococcus aureus was the leading pathogen identified in children with sepsis/septic shock (incidence, 4.42 per 100 000 Indigenous children per year; 0.57 per 100 000 non-Indigenous children per year; incidence rate ratio 7.7; 95% CI, 5.8-10.1; P < 0.001). While crude and risk-adjusted ICU mortality related to invasive infections was not significantly different for Indigenous and non-Indigenous children (odds ratio, 0.75; 95% CI, 0.53-1.07; P = 0.12), the estimated population-based age-standardised mortality rate for invasive infections was significantly higher for Indigenous children (2.67 per 100 000 per year v 1.04 per 100 000 per year; crude incidence rate ratio, 2.65; 95% CI, 1.88e3.64; P < 0.001). Conclusions: The ICU admission rate for severe infections was several times higher for Indigenous than for non-Indigenous children, particularly for S. aureus infections. While ICU case fatality rates were similar, the population-based mortality was more than twice as high for Indigenous children. Our study highlights an important area of inequality in health care for Indigenous children in a high income country that needs urgent attention.

AB - Objectives: To describe the incidence and mortality of invasive infections in Indigenous children admitted to paediatric and general intensive care units (ICUs) in Australia. Design: Retrospective multi-centre cohort study of Australian and New Zealand Paediatric Intensive Care Registry data. Participants: All children under 16 years of age admitted to an ICU in Australia, 1 January 2002 e 31 December 2013. Indigenous children were defined as those identified as Aboriginal and/or Torres Strait Islander in a mandatory admissions dataset. Main outcomes: Population-based ICU mortality and admission rates. Results: Invasive infections accounted for 23.0% of non-elective ICU admissions of Indigenous children (726 of 3150), resulting in an admission rate of 47.6 per 100 000 children per year. Staphylococcus aureus was the leading pathogen identified in children with sepsis/septic shock (incidence, 4.42 per 100 000 Indigenous children per year; 0.57 per 100 000 non-Indigenous children per year; incidence rate ratio 7.7; 95% CI, 5.8-10.1; P < 0.001). While crude and risk-adjusted ICU mortality related to invasive infections was not significantly different for Indigenous and non-Indigenous children (odds ratio, 0.75; 95% CI, 0.53-1.07; P = 0.12), the estimated population-based age-standardised mortality rate for invasive infections was significantly higher for Indigenous children (2.67 per 100 000 per year v 1.04 per 100 000 per year; crude incidence rate ratio, 2.65; 95% CI, 1.88e3.64; P < 0.001). Conclusions: The ICU admission rate for severe infections was several times higher for Indigenous than for non-Indigenous children, particularly for S. aureus infections. While ICU case fatality rates were similar, the population-based mortality was more than twice as high for Indigenous children. Our study highlights an important area of inequality in health care for Indigenous children in a high income country that needs urgent attention.

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Ostrowski JA, MacLaren G, Alexander J, Stewart P, Gune S, Francis JR et al. The burden of invasive infections in critically ill indigenous children in Australia. Medical Journal of Australia. 2017;206(2):78-84. https://doi.org/10.5694/mja16.00595