The burden of cancer attributable to modifiable risk factors

The Australian cancer-PAF cohort consortium

Maria E. Arriaga, Claire M Vajdic, Karen Canfell, Robert MacInnis, Peter Hull, Dianna J. Magliano, Emily Banks, Graham G. Giles, Robert G. Cumming, Julie E. Byles, Anne Taylor, Jonathan E. Shaw, Kay Price, Vasant Hirani, Paul Mitchell, Barbara Ann Adelstein, Maarit A. Laaksonen

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Purpose To estimate the Australian cancer burden attributable to lifestyle-related risk factors and their combinations using a novel population attributable fraction (PAF) method that accounts for competing risk of death, risk factor interdependence and statistical uncertainty. Participants 365 173 adults from seven Australian cohort studies. We linked pooled harmonised individual participant cohort data with population-based cancer and death registries to estimate exposure-cancer and exposure-death associations. Current Australian exposure prevalence was estimated from representative external sources. To illustrate the utility of the new PAF method, we calculated fractions of cancers causally related to body fatness or both tobacco and alcohol consumption avoidable in the next 10 years by risk factor modifications, comparing them with fractions produced by traditional PAF methods. Findings to date Over 10 years of follow-up, we observed 27 483 incident cancers and 22 078 deaths. Of cancers related to body fatness (n=9258), 13% (95% CI 11% to 16%) could be avoided if those currently overweight or obese had body mass index of 18.5-24.9 kg/m 2. Of cancers causally related to both tobacco and alcohol (n=4283), current or former smoking explains 13% (11% to 16%) and consuming more than two alcoholic drinks per day explains 6% (5% to 8%). The two factors combined explain 16% (13% to 19%): 26% (21% to 30%) in men and 8% (4% to 11%) in women. Corresponding estimates using the traditional PAF method were 20%, 31% and 10%. Our PAF estimates translate to 74 000 avoidable body fatness-related cancers and 40 000 avoidable tobacco-and alcohol-related cancers in Australia over the next 10 years (2017-2026). Traditional PAF methods not accounting for competing risk of death and interdependence of risk factors may overestimate PAFs and avoidable cancers. Future plans We will rank the most important causal factors and their combinations for a spectrum of cancers and inform cancer control activities.

Original languageEnglish
Article numbere016178
JournalBMJ Open
Volume7
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017
Externally publishedYes

Keywords

  • burden of disease
  • cancer
  • cohort
  • modifiable risk factors
  • pooling
  • population attributable fraction

Cite this

Arriaga, M. E., Vajdic, C. M., Canfell, K., MacInnis, R., Hull, P., Magliano, D. J., ... Laaksonen, M. A. (2017). The burden of cancer attributable to modifiable risk factors: The Australian cancer-PAF cohort consortium. BMJ Open, 7(6), [e016178]. https://doi.org/10.1136/bmjopen-2017-016178
Arriaga, Maria E. ; Vajdic, Claire M ; Canfell, Karen ; MacInnis, Robert ; Hull, Peter ; Magliano, Dianna J. ; Banks, Emily ; Giles, Graham G. ; Cumming, Robert G. ; Byles, Julie E. ; Taylor, Anne ; Shaw, Jonathan E. ; Price, Kay ; Hirani, Vasant ; Mitchell, Paul ; Adelstein, Barbara Ann ; Laaksonen, Maarit A. / The burden of cancer attributable to modifiable risk factors : The Australian cancer-PAF cohort consortium. In: BMJ Open. 2017 ; Vol. 7, No. 6.
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abstract = "Purpose To estimate the Australian cancer burden attributable to lifestyle-related risk factors and their combinations using a novel population attributable fraction (PAF) method that accounts for competing risk of death, risk factor interdependence and statistical uncertainty. Participants 365 173 adults from seven Australian cohort studies. We linked pooled harmonised individual participant cohort data with population-based cancer and death registries to estimate exposure-cancer and exposure-death associations. Current Australian exposure prevalence was estimated from representative external sources. To illustrate the utility of the new PAF method, we calculated fractions of cancers causally related to body fatness or both tobacco and alcohol consumption avoidable in the next 10 years by risk factor modifications, comparing them with fractions produced by traditional PAF methods. Findings to date Over 10 years of follow-up, we observed 27 483 incident cancers and 22 078 deaths. Of cancers related to body fatness (n=9258), 13{\%} (95{\%} CI 11{\%} to 16{\%}) could be avoided if those currently overweight or obese had body mass index of 18.5-24.9 kg/m 2. Of cancers causally related to both tobacco and alcohol (n=4283), current or former smoking explains 13{\%} (11{\%} to 16{\%}) and consuming more than two alcoholic drinks per day explains 6{\%} (5{\%} to 8{\%}). The two factors combined explain 16{\%} (13{\%} to 19{\%}): 26{\%} (21{\%} to 30{\%}) in men and 8{\%} (4{\%} to 11{\%}) in women. Corresponding estimates using the traditional PAF method were 20{\%}, 31{\%} and 10{\%}. Our PAF estimates translate to 74 000 avoidable body fatness-related cancers and 40 000 avoidable tobacco-and alcohol-related cancers in Australia over the next 10 years (2017-2026). Traditional PAF methods not accounting for competing risk of death and interdependence of risk factors may overestimate PAFs and avoidable cancers. Future plans We will rank the most important causal factors and their combinations for a spectrum of cancers and inform cancer control activities.",
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author = "Arriaga, {Maria E.} and Vajdic, {Claire M} and Karen Canfell and Robert MacInnis and Peter Hull and Magliano, {Dianna J.} and Emily Banks and Giles, {Graham G.} and Cumming, {Robert G.} and Byles, {Julie E.} and Anne Taylor and Shaw, {Jonathan E.} and Kay Price and Vasant Hirani and Paul Mitchell and Adelstein, {Barbara Ann} and Laaksonen, {Maarit A.}",
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Arriaga, ME, Vajdic, CM, Canfell, K, MacInnis, R, Hull, P, Magliano, DJ, Banks, E, Giles, GG, Cumming, RG, Byles, JE, Taylor, A, Shaw, JE, Price, K, Hirani, V, Mitchell, P, Adelstein, BA & Laaksonen, MA 2017, 'The burden of cancer attributable to modifiable risk factors: The Australian cancer-PAF cohort consortium', BMJ Open, vol. 7, no. 6, e016178. https://doi.org/10.1136/bmjopen-2017-016178

The burden of cancer attributable to modifiable risk factors : The Australian cancer-PAF cohort consortium. / Arriaga, Maria E.; Vajdic, Claire M; Canfell, Karen; MacInnis, Robert; Hull, Peter; Magliano, Dianna J.; Banks, Emily; Giles, Graham G.; Cumming, Robert G.; Byles, Julie E.; Taylor, Anne; Shaw, Jonathan E.; Price, Kay; Hirani, Vasant; Mitchell, Paul; Adelstein, Barbara Ann; Laaksonen, Maarit A.

In: BMJ Open, Vol. 7, No. 6, e016178, 01.06.2017.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The burden of cancer attributable to modifiable risk factors

T2 - The Australian cancer-PAF cohort consortium

AU - Arriaga, Maria E.

AU - Vajdic, Claire M

AU - Canfell, Karen

AU - MacInnis, Robert

AU - Hull, Peter

AU - Magliano, Dianna J.

AU - Banks, Emily

AU - Giles, Graham G.

AU - Cumming, Robert G.

AU - Byles, Julie E.

AU - Taylor, Anne

AU - Shaw, Jonathan E.

AU - Price, Kay

AU - Hirani, Vasant

AU - Mitchell, Paul

AU - Adelstein, Barbara Ann

AU - Laaksonen, Maarit A.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Purpose To estimate the Australian cancer burden attributable to lifestyle-related risk factors and their combinations using a novel population attributable fraction (PAF) method that accounts for competing risk of death, risk factor interdependence and statistical uncertainty. Participants 365 173 adults from seven Australian cohort studies. We linked pooled harmonised individual participant cohort data with population-based cancer and death registries to estimate exposure-cancer and exposure-death associations. Current Australian exposure prevalence was estimated from representative external sources. To illustrate the utility of the new PAF method, we calculated fractions of cancers causally related to body fatness or both tobacco and alcohol consumption avoidable in the next 10 years by risk factor modifications, comparing them with fractions produced by traditional PAF methods. Findings to date Over 10 years of follow-up, we observed 27 483 incident cancers and 22 078 deaths. Of cancers related to body fatness (n=9258), 13% (95% CI 11% to 16%) could be avoided if those currently overweight or obese had body mass index of 18.5-24.9 kg/m 2. Of cancers causally related to both tobacco and alcohol (n=4283), current or former smoking explains 13% (11% to 16%) and consuming more than two alcoholic drinks per day explains 6% (5% to 8%). The two factors combined explain 16% (13% to 19%): 26% (21% to 30%) in men and 8% (4% to 11%) in women. Corresponding estimates using the traditional PAF method were 20%, 31% and 10%. Our PAF estimates translate to 74 000 avoidable body fatness-related cancers and 40 000 avoidable tobacco-and alcohol-related cancers in Australia over the next 10 years (2017-2026). Traditional PAF methods not accounting for competing risk of death and interdependence of risk factors may overestimate PAFs and avoidable cancers. Future plans We will rank the most important causal factors and their combinations for a spectrum of cancers and inform cancer control activities.

AB - Purpose To estimate the Australian cancer burden attributable to lifestyle-related risk factors and their combinations using a novel population attributable fraction (PAF) method that accounts for competing risk of death, risk factor interdependence and statistical uncertainty. Participants 365 173 adults from seven Australian cohort studies. We linked pooled harmonised individual participant cohort data with population-based cancer and death registries to estimate exposure-cancer and exposure-death associations. Current Australian exposure prevalence was estimated from representative external sources. To illustrate the utility of the new PAF method, we calculated fractions of cancers causally related to body fatness or both tobacco and alcohol consumption avoidable in the next 10 years by risk factor modifications, comparing them with fractions produced by traditional PAF methods. Findings to date Over 10 years of follow-up, we observed 27 483 incident cancers and 22 078 deaths. Of cancers related to body fatness (n=9258), 13% (95% CI 11% to 16%) could be avoided if those currently overweight or obese had body mass index of 18.5-24.9 kg/m 2. Of cancers causally related to both tobacco and alcohol (n=4283), current or former smoking explains 13% (11% to 16%) and consuming more than two alcoholic drinks per day explains 6% (5% to 8%). The two factors combined explain 16% (13% to 19%): 26% (21% to 30%) in men and 8% (4% to 11%) in women. Corresponding estimates using the traditional PAF method were 20%, 31% and 10%. Our PAF estimates translate to 74 000 avoidable body fatness-related cancers and 40 000 avoidable tobacco-and alcohol-related cancers in Australia over the next 10 years (2017-2026). Traditional PAF methods not accounting for competing risk of death and interdependence of risk factors may overestimate PAFs and avoidable cancers. Future plans We will rank the most important causal factors and their combinations for a spectrum of cancers and inform cancer control activities.

KW - burden of disease

KW - cancer

KW - cohort

KW - modifiable risk factors

KW - pooling

KW - population attributable fraction

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U2 - 10.1136/bmjopen-2017-016178

DO - 10.1136/bmjopen-2017-016178

M3 - Article

VL - 7

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

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