TY - JOUR
T1 - The BRCA1 C-terminal domain: structure and function
AU - Huyton, Trevor
AU - Bates, Paul A
AU - Zhang, Xiaodong
AU - Sternberg, Michael J E
AU - Freemont, Paul S
PY - 2000
Y1 - 2000
N2 - The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and functional diversity of the BRCT superfamily suggests that BRCT domains are evolutionarily convenient interaction modules.
AB - The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and functional diversity of the BRCT superfamily suggests that BRCT domains are evolutionarily convenient interaction modules.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10946236
U2 - 10.1016/S0921-8777(00)00034-3
DO - 10.1016/S0921-8777(00)00034-3
M3 - Article
SN - 1568-7864
VL - 460
SP - 319
EP - 332
JO - DNA Repair
JF - DNA Repair
IS - 3-4
ER -