The BRCA1 C-terminal domain: structure and function

Trevor Huyton, Paul A Bates, Xiaodong Zhang, Michael J E Sternberg, Paul S Freemont

Research output: Contribution to journalArticleResearchpeer-review

132 Citations (Scopus)


The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and functional diversity of the BRCT superfamily suggests that BRCT domains are evolutionarily convenient interaction modules.
Original languageEnglish
Pages (from-to)319 - 332
Number of pages14
JournalDNA Repair
Issue number3-4
Publication statusPublished - 2000

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