The biochemical effects of restricting chloride-rich fluids in intensive care

Nor'azim Mohd Yunos, In Byung, Rinaldo Bellomo, Michael Bailey, Lisa Mclin, David Story, Geoff Gutteridge, Graeme Hart

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Objective: To determine the biochemical effects of restricting the use of chloride-rich intravenous fluids in critically ill patients. Design: Prospective, open-label, before-and-after study. Setting: University-affiliated intensive care unit. Patients: A cohort of 828 consecutive patients admitted over 6 months from February 2008 and cohort of 816 consecutive patients admitted over 6 months from February 2009. Interventions: We collected biochemical and fluid use data during standard practice without clinician awareness. After a 6-month period of education and preparation, we restricted the use of chloride-rich fluids (0.9 saline, Gelofusine, and Albumex 4) in the intensive care unit and made them available only on specific intensive care unit specialist prescription.
Original languageEnglish
Pages (from-to)2419 - 2424
Number of pages6
JournalCritical Care Medicine
Issue number11
Publication statusPublished - 2011

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