TY - JOUR
T1 - The bile acid receptor TGR5 does not interact with b-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts
AU - Jensen, Dane D
AU - Godfrey, Cody B
AU - Niklas, Christian
AU - Canals, Meritxell
AU - Kocan, Martina
AU - Poole, Daniel Philip
AU - Murphy, Jane E
AU - Alemi, Farzad
AU - Cottrell, Graeme S
AU - Korbmacher, Christoph
AU - Lambert, Nevin
AU - Bunnett, Nigel William
AU - Corvera, Carlos U
PY - 2013
Y1 - 2013
N2 - Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with ?-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.
AB - Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with ?-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.
UR - http://www.jbc.org/content/288/32/22942
U2 - 10.1074/jbc.M113.455774
DO - 10.1074/jbc.M113.455774
M3 - Article
SN - 0021-9258
VL - 288
SP - 22942
EP - 22960
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 32
ER -