The bile acid receptor TGR5 does not interact with b-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts

Dane D Jensen, Cody B Godfrey, Christian Niklas, Meritxell Canals, Martina Kocan, Daniel Philip Poole, Jane E Murphy, Farzad Alemi, Graeme S Cottrell, Christoph Korbmacher, Nevin Lambert, Nigel William Bunnett, Carlos U Corvera

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75 Citations (Scopus)

Abstract

Background: The TGR5 bile acid receptor controls energy balance, inflammation, and digestion, but TGR5 signaling is poorly understood. Results: TGR5 does not interact with ?-arrestins, internalize, or desensitize, but signals from plasma membrane rafts. Conclusion: TGR5 transmits sustained signals close to the cell surface. Significance: Understanding TGR5 signaling will facilitate design of TGR5 agonists for metabolic, inflammatory, and digestive disorders.
Original languageEnglish
Pages (from-to)22942 - 22960
Number of pages19
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
Publication statusPublished - 2013

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