TY - JOUR
T1 - The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity
AU - Vincent, Fabien B.
AU - Saulep-Easton, Damien
AU - Figgett, William A.
AU - Fairfax, Kirsten A.
AU - Mackay, Fabienne
PY - 2013
Y1 - 2013
N2 - The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.
AB - The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.
UR - http://www.sciencedirect.com/science/article/pii/S1359610113000312
U2 - 10.1016/j.cytogfr.2013.04.003
DO - 10.1016/j.cytogfr.2013.04.003
M3 - Review Article
SN - 1359-6101
VL - 24
SP - 203
EP - 215
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
IS - 3
ER -
