The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity

Fabien B. Vincent, Damien Saulep-Easton, William A. Figgett, Kirsten A. Fairfax, Fabienne Mackay

Research output: Contribution to journalReview ArticleResearchpeer-review

182 Citations (Scopus)

Abstract

The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.
Original languageEnglish
Pages (from-to)203 - 215
Number of pages13
JournalCytokine and Growth Factor Reviews
Volume24
Issue number3
DOIs
Publication statusPublished - 2013

Cite this

Vincent, Fabien B. ; Saulep-Easton, Damien ; Figgett, William A. ; Fairfax, Kirsten A. ; Mackay, Fabienne. / The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity. In: Cytokine and Growth Factor Reviews. 2013 ; Vol. 24, No. 3. pp. 203 - 215.
@article{d22aa25b57694907bbd63e1700187250,
title = "The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity",
abstract = "The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.",
author = "Vincent, {Fabien B.} and Damien Saulep-Easton and Figgett, {William A.} and Fairfax, {Kirsten A.} and Fabienne Mackay",
year = "2013",
doi = "10.1016/j.cytogfr.2013.04.003",
language = "English",
volume = "24",
pages = "203 -- 215",
journal = "Cytokine and Growth Factor Reviews",
issn = "1359-6101",
publisher = "Pergamon",
number = "3",

}

The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity. / Vincent, Fabien B.; Saulep-Easton, Damien; Figgett, William A.; Fairfax, Kirsten A.; Mackay, Fabienne.

In: Cytokine and Growth Factor Reviews, Vol. 24, No. 3, 2013, p. 203 - 215.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity

AU - Vincent, Fabien B.

AU - Saulep-Easton, Damien

AU - Figgett, William A.

AU - Fairfax, Kirsten A.

AU - Mackay, Fabienne

PY - 2013

Y1 - 2013

N2 - The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.

AB - The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.

UR - http://www.sciencedirect.com/science/article/pii/S1359610113000312

U2 - 10.1016/j.cytogfr.2013.04.003

DO - 10.1016/j.cytogfr.2013.04.003

M3 - Review Article

VL - 24

SP - 203

EP - 215

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

SN - 1359-6101

IS - 3

ER -