The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity

Fabien B. Vincent, Damien Saulep-Easton, William A. Figgett, Kirsten A. Fairfax, Fabienne Mackay

Research output: Contribution to journalReview ArticleResearchpeer-review

199 Citations (Scopus)

Abstract

The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.
Original languageEnglish
Pages (from-to)203 - 215
Number of pages13
JournalCytokine and Growth Factor Reviews
Volume24
Issue number3
DOIs
Publication statusPublished - 2013

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