The bacteriocin piscicolin 126 retains antilisterial activity in vivo

Aaron Ingham, Mark Ford, Robert J. Moore, Mark Tizard

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34 Citations (Scopus)

Abstract

Objective: We have conducted a series of experiments to show that the bacteriocin piscicolin 126 (P126) retains antilisterial activity after injection into a mouse. Methods: Groups of mice were challenged intravenously with Listeria monocytogenes and treated with purified P126 at varying times before and after challenge to determine whether administration of this peptide reduced numbers of colonizing L. monocytogenes and the symptoms of listeriosis. Results: The bacterlocin P126 retained antilisterial activity after injection into the mouse. During the early time-points of listerial infection, the purified P126 was found to significantly reduce the listerial load in the liver and spleen and, further, that this reduction translated to reduced clinical signs of disease. Conclusions: This is the first report of a Class IIA bacteriocin displaying in vivo antimicrobial activity. Such a result provides preliminary evidence that this class of molecules may be useful in controlling systemic bacterial infections.

Original languageEnglish
Pages (from-to)1365-1371
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume51
Issue number6
DOIs
Publication statusPublished - 1 Jun 2003

Keywords

  • Bacteriocin
  • In vivo activity
  • Piscicolin 126

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