The b-cell response to protein antigens in immunity and transplantation

David M. Tarlinton, Facundo Batista, Kenneth G.C. Smith

Research output: Contribution to journalReview ArticleResearchpeer-review

22 Citations (Scopus)

Abstract

The potential for B cells to play a role in transplantation has been recently increasingly recognized. Given that the field has focused almost exclusively on the T cell, here we review B-cell biology. We first describe the B-cell response to protein antigen, and then examine the antibody-independent effector functions of B cells, in particular antigen presentation to T cells. Finally we use autoimmunity as an analogy to focus on the potential role for B cells in transplantation. The direct evidence for this is then marshalled in the accompanying article by Zarkhin and Sarwal.

Original languageEnglish
Pages (from-to)1698-1704
Number of pages7
JournalTransplantation
Volume85
Issue number12
DOIs
Publication statusPublished - 27 Jun 2008

Keywords

  • Antibody
  • Antigen presentation
  • B cell
  • Transplantation

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