The Australian Traumatic Brain Injury Initiative: Systematic Review and Consensus Process to Determine the Predictive Value of Pre-existing Health Conditions for People with Moderate-Severe Traumatic Brain Injury

Ana Antonic-Baker, Clarissa Auvrez, Gerard Tao, Matthew K. Bagg, Adelle Gadowski, Ancelin McKimmie, Amelia J. Hicks, Regina Hill, Lorena Romero, Jennie L. Ponsford, Natasha A. Lannin, Belinda J. Gabbe, Peter A. Cameron, D. Jamie Cooper, Nick Rushworth, Melinda Fitzgerald, Terence J. O'Brien, the AUS-TBI Initiative Investigators

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The first aim of the Australian Traumatic Brain Injury Initiative (AUS-TBI) encompasses development of a set of measures that comprehensively predict outcomes for people with moderate-severe TBI across Australia. This process engaged diverse stakeholders and information sources across six areas: social, health, and clinical factors; biological markers; treatments; and longer-term outcomes. Here, we report the systematic review of pre-existing health conditions as predictors of outcome for people with moderate-severe TBI. Standardized searches were implemented across databases until March 31, 2022. English-language reports of studies evaluating association between pre-existing health conditions and clinical outcome in at least 10 patients with moderate-severe TBI were included. A predefined algorithm was used to assign a judgement of predictive value to each observed association. The list of identified pre-existing health conditions was then discussed with key stakeholders during a consensus meeting to determine the feasibility of incorporating them into standard care. The searches retrieved 22, 217 records, of which 47 articles were included. The process led to identification of 88 unique health predictors (homologized to 21 predictor categories) of 55 outcomes (homologized to 19 outcome categories). Only pre-existing health conditions with high and moderate predictive values were discussed during the consensus meeting. Following the consensus meeting, 5 out of 11 were included (migraine, mental health conditions, ‡4 pre-existing health conditions, osteoporosis, and body mass index [BMI]) as common data elements in the AUS-TBI data dictionary. Upon further discussion, 3 additional pre-existing health conditions were included. These are pre-existing heart disease, frailty score, and previous incidence of TBI.
Original languageEnglish
Number of pages15
JournalJournal of Neurotrauma
Publication statusAccepted/In press - 2024


  • brain injuries, traumatic
  • common data elements
  • comorbidity
  • health care
  • mental health
  • multiple chronic conditions
  • outcome assessment, systematic review [publication type]

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