Abstract
Background: Excess adiposity and adiposity-related inflammation are known risk factors for cardiovascular disease in adults; however, little is known regarding the determinants of adiposity-related inflammation at birth. Objectives: The aim of this study was to investigate the association between maternal pre-pregnancy BMI and newborn adiposity and inflammation. Methods: Paired maternal (28-week gestation) and infant (umbilical cord) blood samples were collected from a population-derived birth cohort (Barwon Infant Study, n=1074). Data on maternal comorbidities and infant birth anthropomorphic measures were compiled, and infant aortic intima-media thickness was measured by trans-abdominal ultrasound. In a selected subgroup of term infants (n=161), matched maternal and cord lipids, high-sensitivity C-reactive protein (hsCRP) and maternal soluble CD14 were measured. Analysis was completed by using pairwise correlation and linear regression. Because of their non-normal distribution, pathology blood measures were log transformed prior to analysis. Results: Maternal pre-pregnancy BMI was positively associated with increased birth weight (mean difference 17.8g per kgm-2, 95% CI 6.6 to 28.9; p=0.002), newborn mean skin-fold thickness (mean difference 0.1mm per kgm-2, 95% CI 0.0 to 0.1; p<0.001) and cord blood hsCRP (mean difference of 4.2% increase in hsCRP per kgm-2 increase in pre-pregnancy BMI, 95% CI 0.6 to 7.7%, p=0.02), but not cord blood soluble CD14. Inclusion of maternal hsCRP as a covariate attenuated the associations between pre-pregnancy BMI and both newborn skin-fold thickness and cord blood hsCRP. Conclusion: Higher maternal pre-pregnancy BMI is associated with increased newborn adiposity and inflammation. These associations may be partially mediated by maternal inflammation during pregnancy.
| Original language | English |
|---|---|
| Pages (from-to) | 46-53 |
| Number of pages | 8 |
| Journal | Pediatric Obesity |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2018 |
Keywords
- Neonatal
- Obesity
- Offspring
- Pregnancy
Cite this
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The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn. / Mccloskey, K.; Ponsonby, A.-L.; Collier, F.; Allen, K.; Tang, M. L.K.; Carlin, J. B.; Saffery, R.; Skilton, M. R.; Cheung, M.; Ranganathan, S.; Dwyer, T.; Burgner, D.; Vuillermin, P.
In: Pediatric Obesity, Vol. 13, No. 1, 01.2018, p. 46-53.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn
AU - Mccloskey, K.
AU - Ponsonby, A.-L.
AU - Collier, F.
AU - Allen, K.
AU - Tang, M. L.K.
AU - Carlin, J. B.
AU - Saffery, R.
AU - Skilton, M. R.
AU - Cheung, M.
AU - Ranganathan, S.
AU - Dwyer, T.
AU - Burgner, D.
AU - Vuillermin, P.
PY - 2018/1
Y1 - 2018/1
N2 - Background: Excess adiposity and adiposity-related inflammation are known risk factors for cardiovascular disease in adults; however, little is known regarding the determinants of adiposity-related inflammation at birth. Objectives: The aim of this study was to investigate the association between maternal pre-pregnancy BMI and newborn adiposity and inflammation. Methods: Paired maternal (28-week gestation) and infant (umbilical cord) blood samples were collected from a population-derived birth cohort (Barwon Infant Study, n=1074). Data on maternal comorbidities and infant birth anthropomorphic measures were compiled, and infant aortic intima-media thickness was measured by trans-abdominal ultrasound. In a selected subgroup of term infants (n=161), matched maternal and cord lipids, high-sensitivity C-reactive protein (hsCRP) and maternal soluble CD14 were measured. Analysis was completed by using pairwise correlation and linear regression. Because of their non-normal distribution, pathology blood measures were log transformed prior to analysis. Results: Maternal pre-pregnancy BMI was positively associated with increased birth weight (mean difference 17.8g per kgm-2, 95% CI 6.6 to 28.9; p=0.002), newborn mean skin-fold thickness (mean difference 0.1mm per kgm-2, 95% CI 0.0 to 0.1; p<0.001) and cord blood hsCRP (mean difference of 4.2% increase in hsCRP per kgm-2 increase in pre-pregnancy BMI, 95% CI 0.6 to 7.7%, p=0.02), but not cord blood soluble CD14. Inclusion of maternal hsCRP as a covariate attenuated the associations between pre-pregnancy BMI and both newborn skin-fold thickness and cord blood hsCRP. Conclusion: Higher maternal pre-pregnancy BMI is associated with increased newborn adiposity and inflammation. These associations may be partially mediated by maternal inflammation during pregnancy.
AB - Background: Excess adiposity and adiposity-related inflammation are known risk factors for cardiovascular disease in adults; however, little is known regarding the determinants of adiposity-related inflammation at birth. Objectives: The aim of this study was to investigate the association between maternal pre-pregnancy BMI and newborn adiposity and inflammation. Methods: Paired maternal (28-week gestation) and infant (umbilical cord) blood samples were collected from a population-derived birth cohort (Barwon Infant Study, n=1074). Data on maternal comorbidities and infant birth anthropomorphic measures were compiled, and infant aortic intima-media thickness was measured by trans-abdominal ultrasound. In a selected subgroup of term infants (n=161), matched maternal and cord lipids, high-sensitivity C-reactive protein (hsCRP) and maternal soluble CD14 were measured. Analysis was completed by using pairwise correlation and linear regression. Because of their non-normal distribution, pathology blood measures were log transformed prior to analysis. Results: Maternal pre-pregnancy BMI was positively associated with increased birth weight (mean difference 17.8g per kgm-2, 95% CI 6.6 to 28.9; p=0.002), newborn mean skin-fold thickness (mean difference 0.1mm per kgm-2, 95% CI 0.0 to 0.1; p<0.001) and cord blood hsCRP (mean difference of 4.2% increase in hsCRP per kgm-2 increase in pre-pregnancy BMI, 95% CI 0.6 to 7.7%, p=0.02), but not cord blood soluble CD14. Inclusion of maternal hsCRP as a covariate attenuated the associations between pre-pregnancy BMI and both newborn skin-fold thickness and cord blood hsCRP. Conclusion: Higher maternal pre-pregnancy BMI is associated with increased newborn adiposity and inflammation. These associations may be partially mediated by maternal inflammation during pregnancy.
KW - Neonatal
KW - Obesity
KW - Offspring
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=84990928821&partnerID=8YFLogxK
U2 - 10.1111/ijpo.12187
DO - 10.1111/ijpo.12187
M3 - Article
VL - 13
SP - 46
EP - 53
JO - Pediatric Obesity
JF - Pediatric Obesity
SN - 2047-6302
IS - 1
ER -