The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn

K. Mccloskey, A.-L. Ponsonby, F. Collier, K. Allen, M. L.K. Tang, J. B. Carlin, R. Saffery, M. R. Skilton, M. Cheung, S. Ranganathan, T. Dwyer, D. Burgner, P. Vuillermin

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Excess adiposity and adiposity-related inflammation are known risk factors for cardiovascular disease in adults; however, little is known regarding the determinants of adiposity-related inflammation at birth. Objectives: The aim of this study was to investigate the association between maternal pre-pregnancy BMI and newborn adiposity and inflammation. Methods: Paired maternal (28-week gestation) and infant (umbilical cord) blood samples were collected from a population-derived birth cohort (Barwon Infant Study, n=1074). Data on maternal comorbidities and infant birth anthropomorphic measures were compiled, and infant aortic intima-media thickness was measured by trans-abdominal ultrasound. In a selected subgroup of term infants (n=161), matched maternal and cord lipids, high-sensitivity C-reactive protein (hsCRP) and maternal soluble CD14 were measured. Analysis was completed by using pairwise correlation and linear regression. Because of their non-normal distribution, pathology blood measures were log transformed prior to analysis. Results: Maternal pre-pregnancy BMI was positively associated with increased birth weight (mean difference 17.8g per kgm-2, 95% CI 6.6 to 28.9; p=0.002), newborn mean skin-fold thickness (mean difference 0.1mm per kgm-2, 95% CI 0.0 to 0.1; p<0.001) and cord blood hsCRP (mean difference of 4.2% increase in hsCRP per kgm-2 increase in pre-pregnancy BMI, 95% CI 0.6 to 7.7%, p=0.02), but not cord blood soluble CD14. Inclusion of maternal hsCRP as a covariate attenuated the associations between pre-pregnancy BMI and both newborn skin-fold thickness and cord blood hsCRP. Conclusion: Higher maternal pre-pregnancy BMI is associated with increased newborn adiposity and inflammation. These associations may be partially mediated by maternal inflammation during pregnancy.

Original languageEnglish
Pages (from-to)46-53
Number of pages8
JournalPediatric Obesity
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2018

Keywords

  • Neonatal
  • Obesity
  • Offspring
  • Pregnancy

Cite this

Mccloskey, K., Ponsonby, A-L., Collier, F., Allen, K., Tang, M. L. K., Carlin, J. B., ... Vuillermin, P. (2018). The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn. Pediatric Obesity, 13(1), 46-53. https://doi.org/10.1111/ijpo.12187
Mccloskey, K. ; Ponsonby, A.-L. ; Collier, F. ; Allen, K. ; Tang, M. L.K. ; Carlin, J. B. ; Saffery, R. ; Skilton, M. R. ; Cheung, M. ; Ranganathan, S. ; Dwyer, T. ; Burgner, D. ; Vuillermin, P. / The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn. In: Pediatric Obesity. 2018 ; Vol. 13, No. 1. pp. 46-53.
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abstract = "Background: Excess adiposity and adiposity-related inflammation are known risk factors for cardiovascular disease in adults; however, little is known regarding the determinants of adiposity-related inflammation at birth. Objectives: The aim of this study was to investigate the association between maternal pre-pregnancy BMI and newborn adiposity and inflammation. Methods: Paired maternal (28-week gestation) and infant (umbilical cord) blood samples were collected from a population-derived birth cohort (Barwon Infant Study, n=1074). Data on maternal comorbidities and infant birth anthropomorphic measures were compiled, and infant aortic intima-media thickness was measured by trans-abdominal ultrasound. In a selected subgroup of term infants (n=161), matched maternal and cord lipids, high-sensitivity C-reactive protein (hsCRP) and maternal soluble CD14 were measured. Analysis was completed by using pairwise correlation and linear regression. Because of their non-normal distribution, pathology blood measures were log transformed prior to analysis. Results: Maternal pre-pregnancy BMI was positively associated with increased birth weight (mean difference 17.8g per kgm-2, 95{\%} CI 6.6 to 28.9; p=0.002), newborn mean skin-fold thickness (mean difference 0.1mm per kgm-2, 95{\%} CI 0.0 to 0.1; p<0.001) and cord blood hsCRP (mean difference of 4.2{\%} increase in hsCRP per kgm-2 increase in pre-pregnancy BMI, 95{\%} CI 0.6 to 7.7{\%}, p=0.02), but not cord blood soluble CD14. Inclusion of maternal hsCRP as a covariate attenuated the associations between pre-pregnancy BMI and both newborn skin-fold thickness and cord blood hsCRP. Conclusion: Higher maternal pre-pregnancy BMI is associated with increased newborn adiposity and inflammation. These associations may be partially mediated by maternal inflammation during pregnancy.",
keywords = "Neonatal, Obesity, Offspring, Pregnancy",
author = "K. Mccloskey and A.-L. Ponsonby and F. Collier and K. Allen and Tang, {M. L.K.} and Carlin, {J. B.} and R. Saffery and Skilton, {M. R.} and M. Cheung and S. Ranganathan and T. Dwyer and D. Burgner and P. Vuillermin",
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Mccloskey, K, Ponsonby, A-L, Collier, F, Allen, K, Tang, MLK, Carlin, JB, Saffery, R, Skilton, MR, Cheung, M, Ranganathan, S, Dwyer, T, Burgner, D & Vuillermin, P 2018, 'The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn' Pediatric Obesity, vol. 13, no. 1, pp. 46-53. https://doi.org/10.1111/ijpo.12187

The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn. / Mccloskey, K.; Ponsonby, A.-L.; Collier, F.; Allen, K.; Tang, M. L.K.; Carlin, J. B.; Saffery, R.; Skilton, M. R.; Cheung, M.; Ranganathan, S.; Dwyer, T.; Burgner, D.; Vuillermin, P.

In: Pediatric Obesity, Vol. 13, No. 1, 01.2018, p. 46-53.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn

AU - Mccloskey, K.

AU - Ponsonby, A.-L.

AU - Collier, F.

AU - Allen, K.

AU - Tang, M. L.K.

AU - Carlin, J. B.

AU - Saffery, R.

AU - Skilton, M. R.

AU - Cheung, M.

AU - Ranganathan, S.

AU - Dwyer, T.

AU - Burgner, D.

AU - Vuillermin, P.

PY - 2018/1

Y1 - 2018/1

N2 - Background: Excess adiposity and adiposity-related inflammation are known risk factors for cardiovascular disease in adults; however, little is known regarding the determinants of adiposity-related inflammation at birth. Objectives: The aim of this study was to investigate the association between maternal pre-pregnancy BMI and newborn adiposity and inflammation. Methods: Paired maternal (28-week gestation) and infant (umbilical cord) blood samples were collected from a population-derived birth cohort (Barwon Infant Study, n=1074). Data on maternal comorbidities and infant birth anthropomorphic measures were compiled, and infant aortic intima-media thickness was measured by trans-abdominal ultrasound. In a selected subgroup of term infants (n=161), matched maternal and cord lipids, high-sensitivity C-reactive protein (hsCRP) and maternal soluble CD14 were measured. Analysis was completed by using pairwise correlation and linear regression. Because of their non-normal distribution, pathology blood measures were log transformed prior to analysis. Results: Maternal pre-pregnancy BMI was positively associated with increased birth weight (mean difference 17.8g per kgm-2, 95% CI 6.6 to 28.9; p=0.002), newborn mean skin-fold thickness (mean difference 0.1mm per kgm-2, 95% CI 0.0 to 0.1; p<0.001) and cord blood hsCRP (mean difference of 4.2% increase in hsCRP per kgm-2 increase in pre-pregnancy BMI, 95% CI 0.6 to 7.7%, p=0.02), but not cord blood soluble CD14. Inclusion of maternal hsCRP as a covariate attenuated the associations between pre-pregnancy BMI and both newborn skin-fold thickness and cord blood hsCRP. Conclusion: Higher maternal pre-pregnancy BMI is associated with increased newborn adiposity and inflammation. These associations may be partially mediated by maternal inflammation during pregnancy.

AB - Background: Excess adiposity and adiposity-related inflammation are known risk factors for cardiovascular disease in adults; however, little is known regarding the determinants of adiposity-related inflammation at birth. Objectives: The aim of this study was to investigate the association between maternal pre-pregnancy BMI and newborn adiposity and inflammation. Methods: Paired maternal (28-week gestation) and infant (umbilical cord) blood samples were collected from a population-derived birth cohort (Barwon Infant Study, n=1074). Data on maternal comorbidities and infant birth anthropomorphic measures were compiled, and infant aortic intima-media thickness was measured by trans-abdominal ultrasound. In a selected subgroup of term infants (n=161), matched maternal and cord lipids, high-sensitivity C-reactive protein (hsCRP) and maternal soluble CD14 were measured. Analysis was completed by using pairwise correlation and linear regression. Because of their non-normal distribution, pathology blood measures were log transformed prior to analysis. Results: Maternal pre-pregnancy BMI was positively associated with increased birth weight (mean difference 17.8g per kgm-2, 95% CI 6.6 to 28.9; p=0.002), newborn mean skin-fold thickness (mean difference 0.1mm per kgm-2, 95% CI 0.0 to 0.1; p<0.001) and cord blood hsCRP (mean difference of 4.2% increase in hsCRP per kgm-2 increase in pre-pregnancy BMI, 95% CI 0.6 to 7.7%, p=0.02), but not cord blood soluble CD14. Inclusion of maternal hsCRP as a covariate attenuated the associations between pre-pregnancy BMI and both newborn skin-fold thickness and cord blood hsCRP. Conclusion: Higher maternal pre-pregnancy BMI is associated with increased newborn adiposity and inflammation. These associations may be partially mediated by maternal inflammation during pregnancy.

KW - Neonatal

KW - Obesity

KW - Offspring

KW - Pregnancy

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U2 - 10.1111/ijpo.12187

DO - 10.1111/ijpo.12187

M3 - Article

VL - 13

SP - 46

EP - 53

JO - Pediatric Obesity

JF - Pediatric Obesity

SN - 2047-6302

IS - 1

ER -