Projects per year
Abstract
Rationale: Aspirin has positive and negative effects on a number of age-related chronic conditions and there is uncertainty regarding its role in primary prevention in people aged 70 years and over. Aims: To assess whether daily active treatment of 100 mg enteric-coated aspirin will extend the duration of disability-free life in healthy older participants. Design: A double-blind, randomized, placebo-controlled primary prevention trial undertaken in Australia and the United States with careful adjudication of endpoints including stroke. Study outcome: In Australia 16,703 individuals were recruited through general practices across five states and territories, and in the United States, 2411 participants were recruited through 34 clinical sites across the country. Follow-up of participants will finish at the end of 2017 with average follow-up exceeding 4.25 years per person. Discussion: The statistical analysis plan for ASPREE, finalized after closure of recruitment but before the end of patient follow-up, outlines the primary analyses and a range of subgroup and sensitivity analyses. (International Standard Randomized Controlled Trial Number Register ISRCTN83772183 and clinicaltrials.gov Number NCT01038583).
Original language | English |
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Pages (from-to) | 335-338 |
Number of pages | 4 |
Journal | International Journal of Stroke |
Volume | 13 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Apr 2018 |
Keywords
- Aspirin
- clinical trial
- disability free survival
- intracerebral hemorrhage
- ischemic stroke
- protocols
- statistical analysis plan
Projects
- 2 Finished
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ASPREE Completion Project
McNeil, J., Nelson, M., Tonkin, A. & Woods, R.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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A randomised double-blind placebo-controlled trial of aspirin in primary prevention of CVD events or dementia in the aged ID: 334047
McNeil, J., Beilin, L. J., Krum, H., Nelson, M., Reid, C. & Tonkin, A.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/05 → 31/12/09
Project: Research