The art and design of genetic screens: Mouse

Benjamin T. Kile, Douglas J. Hilton

Research output: Contribution to journalReview ArticleResearchpeer-review

68 Citations (Scopus)

Abstract

Humans are mammals, not bacteria or plants, yeast or nematodes, insects or fish. Mice are also mammals, but unlike gorilla and goat, fox and ferret, giraffe and jackal, they are suited perfectly to the laboratory environment and genetic experimentation. In this review, we will summarize the tools, tricks and techniques for executing forward genetic screens in the mouse and argue that this approach is now accessible to most biologists, rather than being the sole domain of large national facilities and specialized genetics laboratories.

Original languageEnglish
Pages (from-to)557-567
Number of pages11
JournalNature Reviews Genetics
Volume6
Issue number7
DOIs
Publication statusPublished - Jul 2005
Externally publishedYes

Cite this