The application of template selectophores for the preparation of molecularly imprinted polymers

Basil Danylec, Lachlan Schwarz, Simon John Harris, Reinhard I Boysen, Milton Thomas William Hearn

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


Molecularly imprinted polymers are versatile materials with wide application scope for the detection, capture and separation of specific compounds present in complex feed stocks. A major challenge associated with their preparation has been the need to sacrifice one mole equivalent of the template molecule to generate the complementary polymer cavities that selectively bind the target molecule. Moreover, template molecules can often be difficult to synthesise, expensive or lack stability. In this study, we describe a new approach, directed at the use of synthetic selectophores, chosen as readily prepared and low cost structural analogues with recognition groups in similar three-dimensional arrangements as found in the target molecule. To validate the approach, a comparative study of selectophores related to the polyphenolic compound (E)-resveratrol has been undertaken using traditional and green chemical synthetic approaches. These molecular mimic compounds were employed as polymer templates and also as binding analytes to interrogate the recognition sites associated with the molecularly imprinted polymers. Importantly, the study confirms that the use of selectophores has the potential to confer practical advantages, including access to more efficient methods for selection and preparation of suitable template molecules with a broader range of molecular diversity, as well as delivering imprinted polymers capable of recognizing the target compound and structurally related products
Original languageEnglish
Pages (from-to)17601-17613
Number of pages13
Issue number9
Publication statusPublished - 2015


  • selectophore
  • template
  • molecularly imprinted polymer
  • resveratrol

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