The apparent inhibition of urothelial DNA synthesis in neonatal rats by dietary saccharin

Terence Lawson, Paul Hertzog

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[3H]Thymidine ([3H]TdR) incorporation into urothelial DNA of male neonatal rats was measured autoradiographically at birth and during the first 3 weeks of life. The rats were derived from control parents and those fed saccharin (1, 3, 5 and 7.5%) in the diet from before pregnancy. [3H]TdR incorporation was inhibited and there were more lightly labeled cells (compared with controls), in all the saccharin-exposed rats in a rough dose-dependent manner. The results, in comparison with controls, suggest that saccharin exposure in utero causes DNA damage in the neonatal urothelium manifesting as reduced thymidine incorporation and a greater proportion of lightly labeled cells.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalCancer Letters
Issue number3
Publication statusPublished - 1 Jan 1981
Externally publishedYes

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