The Amount of BCL6 in B Cells Shortly after Antigen Engagement Determines Their Representation in Subsequent Germinal Centers

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Abstract

Immunization activates multiple B cell clones that then partition into different fates. Robinson et al. show that the amount of BCL6 that an individual clone expresses affects its likelihood of progressing through the early immune response stages, with BCL6 amounts determining which clones enter germinal centers to contribute to long-term immunity.

Original languageEnglish
Pages (from-to)1530-1541.e4
Number of pages16
JournalCell Reports
Volume30
Issue number5
DOIs
Publication statusPublished - 4 Feb 2020

Keywords

  • adaptive immunity
  • antibodies
  • B cell memory
  • B cells
  • BCL6
  • Bcl6 transgene
  • clonal expansion
  • germinal centers
  • humoral immunity
  • immune response
  • pre-germinal center

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