The Amount of BCL6 in B Cells Shortly after Antigen Engagement Determines Their Representation in Subsequent Germinal Centers

Marcus James Robinson; Zhoujie Ding; Catherine Pitt; Erica Janet Brodie; Isaak Quast; David Mathew Tarlinton; Dimitra Zotos

doi:10.1016/j.celrep.2020.01.009

The Amount of BCL6 in B Cells Shortly after Antigen Engagement Determines Their Representation in Subsequent Germinal Centers

Marcus James Robinson, Zhoujie Ding, Catherine Pitt, Erica Janet Brodie, Isaak Quast, David Mathew Tarlinton, Dimitra Zotos

Immunology Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Abstract

Immunization activates multiple B cell clones that then partition into different fates. Robinson et al. show that the amount of BCL6 that an individual clone expresses affects its likelihood of progressing through the early immune response stages, with BCL6 amounts determining which clones enter germinal centers to contribute to long-term immunity.

Original language	English
Pages (from-to)	1530-1541.e4
Number of pages	16
Journal	Cell Reports
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2020.01.009
Publication status	Published - 4 Feb 2020

Keywords

adaptive immunity
antibodies
B cell memory
B cells
BCL6
Bcl6 transgene
clonal expansion
germinal centers
humoral immunity
immune response
pre-germinal center

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10.1016/j.celrep.2020.01.009Licence: CC BY-NC-ND

297766984-oaFinal published version, 3.6 MBLicence: CC BY-NC-ND

Cite this

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title = "The Amount of BCL6 in B Cells Shortly after Antigen Engagement Determines Their Representation in Subsequent Germinal Centers",

abstract = "Immunization activates multiple B cell clones that then partition into different fates. Robinson et al. show that the amount of BCL6 that an individual clone expresses affects its likelihood of progressing through the early immune response stages, with BCL6 amounts determining which clones enter germinal centers to contribute to long-term immunity.",

keywords = "adaptive immunity, antibodies, B cell memory, B cells, BCL6, Bcl6 transgene, clonal expansion, germinal centers, humoral immunity, immune response, pre-germinal center",

author = "Robinson, {Marcus James} and Zhoujie Ding and Catherine Pitt and Brodie, {Erica Janet} and Isaak Quast and Tarlinton, {David Mathew} and Dimitra Zotos",

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AU - Robinson, Marcus James

AU - Ding, Zhoujie

AU - Pitt, Catherine

AU - Brodie, Erica Janet

AU - Quast, Isaak

AU - Tarlinton, David Mathew

AU - Zotos, Dimitra

PY - 2020/2/4

Y1 - 2020/2/4

N2 - Immunization activates multiple B cell clones that then partition into different fates. Robinson et al. show that the amount of BCL6 that an individual clone expresses affects its likelihood of progressing through the early immune response stages, with BCL6 amounts determining which clones enter germinal centers to contribute to long-term immunity.

AB - Immunization activates multiple B cell clones that then partition into different fates. Robinson et al. show that the amount of BCL6 that an individual clone expresses affects its likelihood of progressing through the early immune response stages, with BCL6 amounts determining which clones enter germinal centers to contribute to long-term immunity.

KW - adaptive immunity

KW - antibodies

KW - B cell memory

KW - B cells

KW - BCL6

KW - Bcl6 transgene

KW - clonal expansion

KW - germinal centers

KW - humoral immunity

KW - immune response

KW - pre-germinal center

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DO - 10.1016/j.celrep.2020.01.009

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SN - 2211-1247

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SP - 1530-1541.e4

JO - Cell Reports

JF - Cell Reports

IS - 5

ER -

The Amount of BCL6 in B Cells Shortly after Antigen Engagement Determines Their Representation in Subsequent Germinal Centers

Abstract

Keywords

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The role of IL21 in integrating proliferation, migration and differentiation following B cell activation.

NHMRC Principal Research Fellowship

Cite this

The Amount of BCL6 in B Cells Shortly after Antigen Engagement Determines Their Representation in Subsequent Germinal Centers

Abstract

Keywords

Access to Document

Other files and links

Projects

The role of IL21 in integrating proliferation, migration and differentiation following B cell activation.

NHMRC Principal Research Fellowship

Cite this