The alpha and the beta: protein translocation across mitochondrial and plastid outer membranes

Kip Gabriel, Susan K Buchanan, Trevor James Lithgow

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In the evolution of mitochondria and plastids from endosymbiotic bacteria, most of the proteins that make up these organelles have become encoded by nuclear genes and must therefore be transported across the organellar membranes, following synthesis in the cytosol. The core component of the protein translocation machines in both the mitochondrial and plastid outer membranes appears to be a beta-barrel protein, perhaps a relic from their bacterial ancestry, distinguishing these translocases from the alpha-helical-based protein translocation pores found in all other eukaryotic membranes.
Original languageEnglish
Pages (from-to)36 - 40
Number of pages5
JournalTrends in Biochemical Sciences
Issue number1
Publication statusPublished - 2001

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