The Air and Droplet Dynamics of a Soft Mist Inhaler

Michael Pangestu; Bihai Sun; Alireza Heidarian; Vishal Chaugule; Patrick He; Hui Xin Ong; Imco Sibum; Wietze Nijdam; Nicolas A. Buchmann; Daniela Traini; Julio Soria

The Air and Droplet Dynamics of a Soft Mist Inhaler

Michael Pangestu, Bihai Sun, Alireza Heidarian, Vishal Chaugule, Patrick He, Hui Xin Ong, Imco Sibum, Wietze Nijdam, Nicolas A. Buchmann, Daniela Traini, Julio Soria

Mechanical & Aerospace Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

Abstract

Soft mist inhalers (SMIs) generate low-velocity aerosol sprays that mitigate ballistic deposition compared with other inhaler technologies. This work characterises the coupled airflow and droplet kinematics of the Resyca® Pre-Filled Syringe Inhaler under typical operating conditions using laser-based velocimetry. Instantaneous 2-component – 2-dimensional (2C–2D) air-velocity fields are measured by particle image velocimetry (PIV), while corresponding droplet-velocity fields are obtained using particle tracking velocimetry (PTV) guided by the PIV predictor field. The measurements provide spatially resolved first-order velocity statistics for both phases and quantify their relationship throughout the developing spray. These data offer a high-fidelity experimental basis for understanding air–droplet interactions in SMIs and support the optimisation of future inhaler designs for improved aerosol delivery.

Original language	English
Title of host publication	17th International Conference on Fluid Control, Measurements, and Visualization November 4 – 7, 2025
Publisher	The Netherlands Organization for Scientific Research (NWO)
Publication status	Published - 2025
Event	International Conference on Fluid Control, Measurements, and Visualization 2025 - Delft University of Technology, Delft , Netherlands Duration: 4 Nov 2025 → 7 Nov 2025 Conference number: 17th https://www.flucome2025.com/ (Website/Proceedings)

Conference

Conference	International Conference on Fluid Control, Measurements, and Visualization 2025
Abbreviated title	FLUCOME 2025
Country/Territory	Netherlands
City	Delft
Period	4/11/25 → 7/11/25
Internet address	https://www.flucome2025.com/ (Website/Proceedings)

Access to Document

The Air and Droplet Dynamics of a Soft Mist InhalerFinal published version, 1.72 MB

Cite this

@inproceedings{f84fa87f8e214abb8c78b0e01a21ac01,

title = "The Air and Droplet Dynamics of a Soft Mist Inhaler",

abstract = "Soft mist inhalers (SMIs) generate low-velocity aerosol sprays that mitigate ballistic deposition compared with other inhaler technologies. This work characterises the coupled airflow and droplet kinematics of the Resyca{\textregistered} Pre-Filled Syringe Inhaler under typical operating conditions using laser-based velocimetry. Instantaneous 2-component – 2-dimensional (2C–2D) air-velocity fields are measured by particle image velocimetry (PIV), while corresponding droplet-velocity fields are obtained using particle tracking velocimetry (PTV) guided by the PIV predictor field. The measurements provide spatially resolved first-order velocity statistics for both phases and quantify their relationship throughout the developing spray. These data offer a high-fidelity experimental basis for understanding air–droplet interactions in SMIs and support the optimisation of future inhaler designs for improved aerosol delivery.",

author = "Michael Pangestu and Bihai Sun and Alireza Heidarian and Vishal Chaugule and Patrick He and Ong, \{Hui Xin\} and Imco Sibum and Wietze Nijdam and Buchmann, \{Nicolas A.\} and Daniela Traini and Julio Soria",

year = "2025",

language = "English",

booktitle = "17th International Conference on Fluid Control, Measurements, and Visualization November 4 – 7, 2025",

publisher = "The Netherlands Organization for Scientific Research (NWO)",

note = "International Conference on Fluid Control, Measurements, and Visualization 2025, FLUCOME 2025 ; Conference date: 04-11-2025 Through 07-11-2025",

url = "https://www.flucome2025.com/",

}

Pangestu, M, Sun, B , Heidarian, A, Chaugule, V, He, P, Ong, HX, Sibum, I, Nijdam, W, Buchmann, NA, Traini, D & Soria, J 2025, The Air and Droplet Dynamics of a Soft Mist Inhaler. in 17th International Conference on Fluid Control, Measurements, and Visualization November 4 – 7, 2025. The Netherlands Organization for Scientific Research (NWO), International Conference on Fluid Control, Measurements, and Visualization 2025, Delft , Netherlands, 4/11/25.

The Air and Droplet Dynamics of a Soft Mist Inhaler. / Pangestu, Michael; Sun, Bihai ; Heidarian, Alireza et al.
17th International Conference on Fluid Control, Measurements, and Visualization November 4 – 7, 2025. The Netherlands Organization for Scientific Research (NWO), 2025.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

TY - GEN

T1 - The Air and Droplet Dynamics of a Soft Mist Inhaler

AU - Pangestu, Michael

AU - Sun, Bihai

AU - Heidarian, Alireza

AU - Chaugule, Vishal

AU - He, Patrick

AU - Ong, Hui Xin

AU - Sibum, Imco

AU - Nijdam, Wietze

AU - Buchmann, Nicolas A.

AU - Traini, Daniela

AU - Soria, Julio

N1 - Conference code: 17th

PY - 2025

Y1 - 2025

N2 - Soft mist inhalers (SMIs) generate low-velocity aerosol sprays that mitigate ballistic deposition compared with other inhaler technologies. This work characterises the coupled airflow and droplet kinematics of the Resyca® Pre-Filled Syringe Inhaler under typical operating conditions using laser-based velocimetry. Instantaneous 2-component – 2-dimensional (2C–2D) air-velocity fields are measured by particle image velocimetry (PIV), while corresponding droplet-velocity fields are obtained using particle tracking velocimetry (PTV) guided by the PIV predictor field. The measurements provide spatially resolved first-order velocity statistics for both phases and quantify their relationship throughout the developing spray. These data offer a high-fidelity experimental basis for understanding air–droplet interactions in SMIs and support the optimisation of future inhaler designs for improved aerosol delivery.

AB - Soft mist inhalers (SMIs) generate low-velocity aerosol sprays that mitigate ballistic deposition compared with other inhaler technologies. This work characterises the coupled airflow and droplet kinematics of the Resyca® Pre-Filled Syringe Inhaler under typical operating conditions using laser-based velocimetry. Instantaneous 2-component – 2-dimensional (2C–2D) air-velocity fields are measured by particle image velocimetry (PIV), while corresponding droplet-velocity fields are obtained using particle tracking velocimetry (PTV) guided by the PIV predictor field. The measurements provide spatially resolved first-order velocity statistics for both phases and quantify their relationship throughout the developing spray. These data offer a high-fidelity experimental basis for understanding air–droplet interactions in SMIs and support the optimisation of future inhaler designs for improved aerosol delivery.

M3 - Conference Paper

BT - 17th International Conference on Fluid Control, Measurements, and Visualization November 4 – 7, 2025

PB - The Netherlands Organization for Scientific Research (NWO)

T2 - International Conference on Fluid Control, Measurements, and Visualization 2025

Y2 - 4 November 2025 through 7 November 2025

ER -