Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin angiotensin system (RAS). This enzyme inactivates the potent vasopressive peptide angiotensin II (AngII) by removing the C-terminal phenylalanine residue. ACE2 is also found to be upregulated in the heart in human and animal models of cardiovascular disease and specifically in the human fibrotic liver . Given the role of ACE2 in the RAS and its suspected involvement in other organ systems, a stable and specific inhibitor of low toxicity would be useful in further elucidating the precise role that ACE2 plays in the pathology of heart and liver disease and as a possible therapeutic for hypotension associated with chronic liver failure.
|Title of host publication||Peptides for Youth: The Proceedings of the 20th American Peptide Symposium|
|Editors||S Del Valle, E Escher, W D Lubell|
|Place of Publication||USA|
|Pages||559 - 560|
|Number of pages||2|
|Publication status||Published - 2009|