The activation of the adaptive immune system: Cross-talk between antigen-presenting cells, T cells and B cells

Menno Cornelis van Zelm, Joke M Den Haan, Ramon Arens

Research output: Contribution to journalReview ArticleResearchpeer-review

64 Citations (Scopus)


The adaptive immune system consists of T and B cells that express clonally distributed antigen receptors. To achieve functional adaptive immune responses, antigen-specific T cell populations are stimulated by professional antigen-presenting cells like dendritic cells (DCs), which provide crucial stimulatory signals for efficient expansion and development of effector functions. Antigen-specific B cells receive costimulatory signals from helper T cells to stimulate affinity maturation and isotype switching. Here we elaborate on the interactions between DCs, T cells and B cells, and on the important signals for efficient induction of adaptive immune responses.
Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalImmunology Letters
Issue number2
Publication statusPublished - 2014

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