The 'Aachen' keratoprosthesis: A new approach towards successful keratoprosthesis-surgery

Tatjana Von Fischern, S. Langefeld, L. Yuan, N. Völcker, M. Reim, B. Kirchhof, N. F. Schrage

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background. None of the keratoprostheses available today is absolutely successful in the long term, neither the problems of extrusion, retroprosthetic membrane formation and intraocular pressure rise are yet solved. A new type of keratoprosthesis is required which can show improved ingrowth characteristics and allow intraocular pressure measurements. In order to possibly meet the above mentioned requirements we developed a flexible silicone keratoprosthesis with scleral fixation and chemical surface modification. Methods. The one-piece keratoprosthesis is made of silicone rubber. Its optical zone has a diameter of 11 mm and is 0.3 mm thick. The surface-modified haptic consists of a scleral rim and eight branches for scleral fixation. A ridge at the back of the keratoprosthesis fitting into the trephination hole shall avoid leakage and retroprosthetic membrane formation. Optical and mechanical qualities are characterised by tensile tests, spectrophotometry and topography. Results. A method for keratoprosthesis-production was established. The optical quality of the device was improved by submicron lathing of the mould. Spectrophotometry showed high visible and ultraviolet light transmission of the silicone. Mechanical tests with silicone samples revealed high tensile strength and elongation at break. The mechanical properties were not impaired by surface modification. Conclusions. The production of a flexible silicone keratoprosthesis with high optical and mechanical properties was established. Its use both for the treatment of permanently opacified corneas and as temporary keratoprosthesis seems to be possible.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalInternational Journal of Artificial Organs
Volume22
Issue number1
Publication statusPublished - 1 Jan 1999
Externally publishedYes

Keywords

  • Keratoprosthesis
  • Silicone
  • Tensile strength
  • Topography
  • UV-absorption

Cite this

Von Fischern, T., Langefeld, S., Yuan, L., Völcker, N., Reim, M., Kirchhof, B., & Schrage, N. F. (1999). The 'Aachen' keratoprosthesis: A new approach towards successful keratoprosthesis-surgery. International Journal of Artificial Organs, 22(1), 52-57.
Von Fischern, Tatjana ; Langefeld, S. ; Yuan, L. ; Völcker, N. ; Reim, M. ; Kirchhof, B. ; Schrage, N. F. / The 'Aachen' keratoprosthesis : A new approach towards successful keratoprosthesis-surgery. In: International Journal of Artificial Organs. 1999 ; Vol. 22, No. 1. pp. 52-57.
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Von Fischern, T, Langefeld, S, Yuan, L, Völcker, N, Reim, M, Kirchhof, B & Schrage, NF 1999, 'The 'Aachen' keratoprosthesis: A new approach towards successful keratoprosthesis-surgery' International Journal of Artificial Organs, vol. 22, no. 1, pp. 52-57.

The 'Aachen' keratoprosthesis : A new approach towards successful keratoprosthesis-surgery. / Von Fischern, Tatjana; Langefeld, S.; Yuan, L.; Völcker, N.; Reim, M.; Kirchhof, B.; Schrage, N. F.

In: International Journal of Artificial Organs, Vol. 22, No. 1, 01.01.1999, p. 52-57.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The 'Aachen' keratoprosthesis

T2 - A new approach towards successful keratoprosthesis-surgery

AU - Von Fischern, Tatjana

AU - Langefeld, S.

AU - Yuan, L.

AU - Völcker, N.

AU - Reim, M.

AU - Kirchhof, B.

AU - Schrage, N. F.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Background. None of the keratoprostheses available today is absolutely successful in the long term, neither the problems of extrusion, retroprosthetic membrane formation and intraocular pressure rise are yet solved. A new type of keratoprosthesis is required which can show improved ingrowth characteristics and allow intraocular pressure measurements. In order to possibly meet the above mentioned requirements we developed a flexible silicone keratoprosthesis with scleral fixation and chemical surface modification. Methods. The one-piece keratoprosthesis is made of silicone rubber. Its optical zone has a diameter of 11 mm and is 0.3 mm thick. The surface-modified haptic consists of a scleral rim and eight branches for scleral fixation. A ridge at the back of the keratoprosthesis fitting into the trephination hole shall avoid leakage and retroprosthetic membrane formation. Optical and mechanical qualities are characterised by tensile tests, spectrophotometry and topography. Results. A method for keratoprosthesis-production was established. The optical quality of the device was improved by submicron lathing of the mould. Spectrophotometry showed high visible and ultraviolet light transmission of the silicone. Mechanical tests with silicone samples revealed high tensile strength and elongation at break. The mechanical properties were not impaired by surface modification. Conclusions. The production of a flexible silicone keratoprosthesis with high optical and mechanical properties was established. Its use both for the treatment of permanently opacified corneas and as temporary keratoprosthesis seems to be possible.

AB - Background. None of the keratoprostheses available today is absolutely successful in the long term, neither the problems of extrusion, retroprosthetic membrane formation and intraocular pressure rise are yet solved. A new type of keratoprosthesis is required which can show improved ingrowth characteristics and allow intraocular pressure measurements. In order to possibly meet the above mentioned requirements we developed a flexible silicone keratoprosthesis with scleral fixation and chemical surface modification. Methods. The one-piece keratoprosthesis is made of silicone rubber. Its optical zone has a diameter of 11 mm and is 0.3 mm thick. The surface-modified haptic consists of a scleral rim and eight branches for scleral fixation. A ridge at the back of the keratoprosthesis fitting into the trephination hole shall avoid leakage and retroprosthetic membrane formation. Optical and mechanical qualities are characterised by tensile tests, spectrophotometry and topography. Results. A method for keratoprosthesis-production was established. The optical quality of the device was improved by submicron lathing of the mould. Spectrophotometry showed high visible and ultraviolet light transmission of the silicone. Mechanical tests with silicone samples revealed high tensile strength and elongation at break. The mechanical properties were not impaired by surface modification. Conclusions. The production of a flexible silicone keratoprosthesis with high optical and mechanical properties was established. Its use both for the treatment of permanently opacified corneas and as temporary keratoprosthesis seems to be possible.

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KW - Silicone

KW - Tensile strength

KW - Topography

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