Abstract
An investigation into the inhibition of protein synthesis by double-stranded RNA in cell-free systems prepared from interferon-treated cells has resulted in the identification of at least two enzymes (the 2-5A synthetase and protein kinase) which are induced in response to interferon. In addition, the discovery that the 2-5A synthetase is present in a wide variety of cells and tissues in the absence of interferon treatment and is also capable of using important metabolites as substrates has suggested a possible wider significance for the 2-5A system in the control of cell growth and development.
Original language | English |
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Pages (from-to) | 138-140 |
Number of pages | 3 |
Journal | Trends in Biochemical Sciences |
Volume | 5 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 1980 |
Externally published | Yes |