The 2-5A (pppA2′ p5′ A2′ p5′ A) system in interferon-treated and control cells

Bryan R.G. Williams, Ian M. Kerr

Research output: Contribution to journalReview ArticleResearchpeer-review

36 Citations (Scopus)


An investigation into the inhibition of protein synthesis by double-stranded RNA in cell-free systems prepared from interferon-treated cells has resulted in the identification of at least two enzymes (the 2-5A synthetase and protein kinase) which are induced in response to interferon. In addition, the discovery that the 2-5A synthetase is present in a wide variety of cells and tissues in the absence of interferon treatment and is also capable of using important metabolites as substrates has suggested a possible wider significance for the 2-5A system in the control of cell growth and development.

Original languageEnglish
Pages (from-to)138-140
Number of pages3
JournalTrends in Biochemical Sciences
Issue number5
Publication statusPublished - May 1980
Externally publishedYes

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