TY - JOUR
T1 - The 1984 Tasmanian insulin treated diabetes mellitus prevalence cohort
T2 - An eight and a half year mortality follow-up investigation
AU - Riley, M. D.
AU - McCarty, D. J.
AU - Couper, D. J.
AU - Humphrey, A. R.G.
AU - Dwyer, T.
AU - Zimmet, P. Z.
PY - 1995/7
Y1 - 1995/7
N2 - Total mortality and underlying cause of death were examined in a population-based prevalence cohort (n = 1232) of Tasmanians with insulin-treated diabetes mellitus. Eight and a half years after the establishment of the registry, the cause of death based on death certificate information was determined for the overall cohort and for three clasification groups of insulin-treated diabetes: Group A - childhood-onset IDDM cases; Group B - adult-onset IDDM cases; and Group C - adult-onset insulin-treated NIDDM cases. A total of 378 deaths occurred, providing an overall SMR of 2.2 (95% CI 2.0-2.4) compared to the Tasmanian population. Diabetic females experienced a higher SMR (2.6, 95% CI 2.3-3.0) than diabetic males (1.9, 95% CI 1.6-2.2). The all-cause SMRs for the diabetic classification groups were 4.6 (95% CI 3.4-6.1) in Group A, 1.8 (95% CI 1.5-2.1) in Group B, and 2.2 (95% CI 1.9-2.6) in Group C. After adjusting for age, gender and duration of diabetes, the mortality in Group C was significantly higher compared to Group B (odds ratio 1.6, 95% CI 1.2-2.3). This study indicates that people with childhood-onset IDDM experience 4.6 times the death rate compared to the Tasmanian population and that the excess mortality is most pronounced in females.
AB - Total mortality and underlying cause of death were examined in a population-based prevalence cohort (n = 1232) of Tasmanians with insulin-treated diabetes mellitus. Eight and a half years after the establishment of the registry, the cause of death based on death certificate information was determined for the overall cohort and for three clasification groups of insulin-treated diabetes: Group A - childhood-onset IDDM cases; Group B - adult-onset IDDM cases; and Group C - adult-onset insulin-treated NIDDM cases. A total of 378 deaths occurred, providing an overall SMR of 2.2 (95% CI 2.0-2.4) compared to the Tasmanian population. Diabetic females experienced a higher SMR (2.6, 95% CI 2.3-3.0) than diabetic males (1.9, 95% CI 1.6-2.2). The all-cause SMRs for the diabetic classification groups were 4.6 (95% CI 3.4-6.1) in Group A, 1.8 (95% CI 1.5-2.1) in Group B, and 2.2 (95% CI 1.9-2.6) in Group C. After adjusting for age, gender and duration of diabetes, the mortality in Group C was significantly higher compared to Group B (odds ratio 1.6, 95% CI 1.2-2.3). This study indicates that people with childhood-onset IDDM experience 4.6 times the death rate compared to the Tasmanian population and that the excess mortality is most pronounced in females.
KW - Epidemiology
KW - IDDM
KW - Mortality
KW - NIDDM
UR - http://www.scopus.com/inward/record.url?scp=0028789481&partnerID=8YFLogxK
U2 - 10.1016/0168-8227(95)01106-N
DO - 10.1016/0168-8227(95)01106-N
M3 - Article
C2 - 8593756
AN - SCOPUS:0028789481
VL - 29
SP - 27
EP - 35
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 1
ER -