The 14-3-3zeta-GPIb-IX-V complex as an antiplatelet target

Robert Keith Andrews, Xiaoping Du, Michael Claude Berndt

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

The functional nexus involving the platelet adhesion receptor, the glycoprotein (GP)Ib-IX-V complex, and the signaling protein, 14-3-3zeta, is emerging as a new drug target for control of GPIb-IX-V-dependent thrombotic diseases such as heart attack and stroke. Together, advances in understanding mechanisms of regulation and functional consequences of the GPIb-IX-V/14-3-3zeta interaction, and the growing potential of 14-3-3-targeting therapeutic approaches used for 14-3-3-dependent processes in other cells--principally involving cell cycling and cancer--point to 14-3-3zeta as a promising antithrombotic target. The unique recognition sequences and arrangement of functional 14-3-3zeta-binding sites found within the cytoplasmic domain of GPIb-IX-V increase the likelihood of selective targeting of this interaction.
Original languageEnglish
Pages (from-to)285 - 292
Number of pages8
JournalDrug News and Perspectives
Volume20
Issue number5
DOIs
Publication statusPublished - 2007

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