The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

Hyeryun Choe; Michael Farzan; Ying Sun; Nancy Sullivan; Barrett Rollins; Paul D. Ponath; Lijun Wu; Charles R. Mackay; Gregory LaRosa; Walter Newman; Norma Gerard; Craig Gerard; Joseph Sodroski

doi:10.1016/S0092-8674(00)81313-6

The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

Hyeryun Choe, Michael Farzan, Ying Sun, Nancy Sullivan, Barrett Rollins, Paul D. Ponath, Lijun Wu, Charles R. Mackay, Gregory LaRosa, Walter Newman, Norma Gerard, Craig Gerard, Joseph Sodroski

Research output: Contribution to journal › Article › Research › peer-review

2093 Citations (Scopus)

Abstract

We examined the ability of chemokine receptors and related G protein- coupled receptors to facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be infected. CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibited infection by these isolates. Utilization of CCR3 and CCR5 on the target cell depended upon the sequence of the third variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein. The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and β-chemokine inhibition of primary HIV-1 isolates.

Original language	English
Pages (from-to)	1135-1148
Number of pages	14
Journal	Cell
Volume	85
Issue number	7
DOIs	https://doi.org/10.1016/S0092-8674(00)81313-6
Publication status	Published - 28 Jun 1996
Externally published	Yes

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10.1016/S0092-8674(00)81313-6

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title = "The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates",

abstract = "We examined the ability of chemokine receptors and related G protein- coupled receptors to facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be infected. CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibited infection by these isolates. Utilization of CCR3 and CCR5 on the target cell depended upon the sequence of the third variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein. The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and β-chemokine inhibition of primary HIV-1 isolates.",

author = "Hyeryun Choe and Michael Farzan and Ying Sun and Nancy Sullivan and Barrett Rollins and Ponath, {Paul D.} and Lijun Wu and Mackay, {Charles R.} and Gregory LaRosa and Walter Newman and Norma Gerard and Craig Gerard and Joseph Sodroski",

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T1 - The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

AU - Choe, Hyeryun

AU - Farzan, Michael

AU - Sun, Ying

AU - Sullivan, Nancy

AU - Rollins, Barrett

AU - Ponath, Paul D.

AU - Wu, Lijun

AU - Mackay, Charles R.

AU - LaRosa, Gregory

AU - Newman, Walter

AU - Gerard, Norma

AU - Gerard, Craig

AU - Sodroski, Joseph

PY - 1996/6/28

Y1 - 1996/6/28

N2 - We examined the ability of chemokine receptors and related G protein- coupled receptors to facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be infected. CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibited infection by these isolates. Utilization of CCR3 and CCR5 on the target cell depended upon the sequence of the third variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein. The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and β-chemokine inhibition of primary HIV-1 isolates.

AB - We examined the ability of chemokine receptors and related G protein- coupled receptors to facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV-1 isolates to be infected. CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibited infection by these isolates. Utilization of CCR3 and CCR5 on the target cell depended upon the sequence of the third variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein. The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and β-chemokine inhibition of primary HIV-1 isolates.

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JO - Cell

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SN - 0092-8674

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The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

Abstract

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