Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages

James Harris, Sharon S Master, Sergio A de Haro, Monica A Delgado, Esteban A Roberts, Jayne C Hope, Joseph Keane, Vojo Deretic

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Autophagy is a major intracellular pathway for the lysosomal degradation of long-lived cytoplasmic macromolecules and damaged or surplus organelles. More recently, autophagy has also been linked with innate and adaptive immune responses against intracellular pathogens, including Mycobacterium tuberculosis, which can survive within macrophages by blocking fusion of the phagosome with lysosomes. Induction of autophagy by the Th1 cytokine IFN-gamma enables infected macrophages to overcome this phagosome maturation block and inhibit the intracellular survival of mycobacteria. Conversely, the Th2 cytokines IL-4 and IL-13 inhibit autophagy in murine and human macrophages. We discuss how differential modulation of autophagy by Th1 and Th2 cytokines may represent an important feature of the host response to mycobacteria.
Original languageEnglish
Pages (from-to)37 - 43
Number of pages7
JournalVeterinary Immunology and Immunopathology
Volume128
Issue number1-3
DOIs
Publication statusPublished - 2009

Cite this

Harris, James ; Master, Sharon S ; de Haro, Sergio A ; Delgado, Monica A ; Roberts, Esteban A ; Hope, Jayne C ; Keane, Joseph ; Deretic, Vojo. / Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages. In: Veterinary Immunology and Immunopathology. 2009 ; Vol. 128, No. 1-3. pp. 37 - 43.
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abstract = "Autophagy is a major intracellular pathway for the lysosomal degradation of long-lived cytoplasmic macromolecules and damaged or surplus organelles. More recently, autophagy has also been linked with innate and adaptive immune responses against intracellular pathogens, including Mycobacterium tuberculosis, which can survive within macrophages by blocking fusion of the phagosome with lysosomes. Induction of autophagy by the Th1 cytokine IFN-gamma enables infected macrophages to overcome this phagosome maturation block and inhibit the intracellular survival of mycobacteria. Conversely, the Th2 cytokines IL-4 and IL-13 inhibit autophagy in murine and human macrophages. We discuss how differential modulation of autophagy by Th1 and Th2 cytokines may represent an important feature of the host response to mycobacteria.",
author = "James Harris and Master, {Sharon S} and {de Haro}, {Sergio A} and Delgado, {Monica A} and Roberts, {Esteban A} and Hope, {Jayne C} and Joseph Keane and Vojo Deretic",
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Harris, J, Master, SS, de Haro, SA, Delgado, MA, Roberts, EA, Hope, JC, Keane, J & Deretic, V 2009, 'Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages' Veterinary Immunology and Immunopathology, vol. 128, no. 1-3, pp. 37 - 43. https://doi.org/10.1016/j.vetimm.2008.10.293

Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages. / Harris, James; Master, Sharon S; de Haro, Sergio A; Delgado, Monica A; Roberts, Esteban A; Hope, Jayne C; Keane, Joseph; Deretic, Vojo.

In: Veterinary Immunology and Immunopathology, Vol. 128, No. 1-3, 2009, p. 37 - 43.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Harris, James

AU - Master, Sharon S

AU - de Haro, Sergio A

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AU - Hope, Jayne C

AU - Keane, Joseph

AU - Deretic, Vojo

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AB - Autophagy is a major intracellular pathway for the lysosomal degradation of long-lived cytoplasmic macromolecules and damaged or surplus organelles. More recently, autophagy has also been linked with innate and adaptive immune responses against intracellular pathogens, including Mycobacterium tuberculosis, which can survive within macrophages by blocking fusion of the phagosome with lysosomes. Induction of autophagy by the Th1 cytokine IFN-gamma enables infected macrophages to overcome this phagosome maturation block and inhibit the intracellular survival of mycobacteria. Conversely, the Th2 cytokines IL-4 and IL-13 inhibit autophagy in murine and human macrophages. We discuss how differential modulation of autophagy by Th1 and Th2 cytokines may represent an important feature of the host response to mycobacteria.

UR - http://www.ncbi.nlm.nih.gov/pubmed/19026454

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