Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 94 - 103 |
| Number of pages | 10 |
| Journal | Seminars in Cell and Developmental Biology |
| Volume | 45 |
| DOIs | |
| Publication status | Published - 2015 |
Cite this
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TGF-beta superfamily signaling in testis formation and early male germline development. / Young, Julia Caitlin; Wakitani, Shoichi; Loveland, Katherine L.
In: Seminars in Cell and Developmental Biology, Vol. 45, 2015, p. 94 - 103.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - TGF-beta superfamily signaling in testis formation and early male germline development
AU - Young, Julia Caitlin
AU - Wakitani, Shoichi
AU - Loveland, Katherine L.
PY - 2015
Y1 - 2015
N2 - The TGF-beta ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germline differentiation. BMPs are essential for the interactive instructions between multiple cell types in the early embryo that drive initial specification of gamete precursors. In the nascent foetal testis, several ligands including Nodal, TGF-betas, Activins and BMPs, serve as key masculinizing switches by regulating male germline pluripotency, somatic and germline proliferation, and testicular vascularization and architecture. In postnatal life, local production of these factors determine adult testis size by regulating Sertoli cell multiplication and differentiation, in addition to specifying germline differentiation and multiplication. Because TGF-beta superfamily signalling is integral to testis formation, it affects processes that underlie testicular pathologies, including testicular cancer, and its potential to contribute to subfertility is beginning to be understood.
AB - The TGF-beta ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germline differentiation. BMPs are essential for the interactive instructions between multiple cell types in the early embryo that drive initial specification of gamete precursors. In the nascent foetal testis, several ligands including Nodal, TGF-betas, Activins and BMPs, serve as key masculinizing switches by regulating male germline pluripotency, somatic and germline proliferation, and testicular vascularization and architecture. In postnatal life, local production of these factors determine adult testis size by regulating Sertoli cell multiplication and differentiation, in addition to specifying germline differentiation and multiplication. Because TGF-beta superfamily signalling is integral to testis formation, it affects processes that underlie testicular pathologies, including testicular cancer, and its potential to contribute to subfertility is beginning to be understood.
UR - http://www.sciencedirect.com/science/article/pii/S108495211500227X
U2 - 10.1016/j.semcdb.2015.10.029
DO - 10.1016/j.semcdb.2015.10.029
M3 - Review Article
VL - 45
SP - 94
EP - 103
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
ER -