TGF-beta superfamily signaling in testis formation and early male germline development

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32 Citations (Scopus)

Abstract

The TGF-beta ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germline differentiation. BMPs are essential for the interactive instructions between multiple cell types in the early embryo that drive initial specification of gamete precursors. In the nascent foetal testis, several ligands including Nodal, TGF-betas, Activins and BMPs, serve as key masculinizing switches by regulating male germline pluripotency, somatic and germline proliferation, and testicular vascularization and architecture. In postnatal life, local production of these factors determine adult testis size by regulating Sertoli cell multiplication and differentiation, in addition to specifying germline differentiation and multiplication. Because TGF-beta superfamily signalling is integral to testis formation, it affects processes that underlie testicular pathologies, including testicular cancer, and its potential to contribute to subfertility is beginning to be understood.
Original languageEnglish
Pages (from-to)94 - 103
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume45
DOIs
Publication statusPublished - 2015

Cite this

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title = "TGF-beta superfamily signaling in testis formation and early male germline development",
abstract = "The TGF-beta ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germline differentiation. BMPs are essential for the interactive instructions between multiple cell types in the early embryo that drive initial specification of gamete precursors. In the nascent foetal testis, several ligands including Nodal, TGF-betas, Activins and BMPs, serve as key masculinizing switches by regulating male germline pluripotency, somatic and germline proliferation, and testicular vascularization and architecture. In postnatal life, local production of these factors determine adult testis size by regulating Sertoli cell multiplication and differentiation, in addition to specifying germline differentiation and multiplication. Because TGF-beta superfamily signalling is integral to testis formation, it affects processes that underlie testicular pathologies, including testicular cancer, and its potential to contribute to subfertility is beginning to be understood.",
author = "Young, {Julia Caitlin} and Shoichi Wakitani and Loveland, {Katherine L.}",
year = "2015",
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pages = "94 -- 103",
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TGF-beta superfamily signaling in testis formation and early male germline development. / Young, Julia Caitlin; Wakitani, Shoichi; Loveland, Katherine L.

In: Seminars in Cell and Developmental Biology, Vol. 45, 2015, p. 94 - 103.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - TGF-beta superfamily signaling in testis formation and early male germline development

AU - Young, Julia Caitlin

AU - Wakitani, Shoichi

AU - Loveland, Katherine L.

PY - 2015

Y1 - 2015

N2 - The TGF-beta ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germline differentiation. BMPs are essential for the interactive instructions between multiple cell types in the early embryo that drive initial specification of gamete precursors. In the nascent foetal testis, several ligands including Nodal, TGF-betas, Activins and BMPs, serve as key masculinizing switches by regulating male germline pluripotency, somatic and germline proliferation, and testicular vascularization and architecture. In postnatal life, local production of these factors determine adult testis size by regulating Sertoli cell multiplication and differentiation, in addition to specifying germline differentiation and multiplication. Because TGF-beta superfamily signalling is integral to testis formation, it affects processes that underlie testicular pathologies, including testicular cancer, and its potential to contribute to subfertility is beginning to be understood.

AB - The TGF-beta ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germline differentiation. BMPs are essential for the interactive instructions between multiple cell types in the early embryo that drive initial specification of gamete precursors. In the nascent foetal testis, several ligands including Nodal, TGF-betas, Activins and BMPs, serve as key masculinizing switches by regulating male germline pluripotency, somatic and germline proliferation, and testicular vascularization and architecture. In postnatal life, local production of these factors determine adult testis size by regulating Sertoli cell multiplication and differentiation, in addition to specifying germline differentiation and multiplication. Because TGF-beta superfamily signalling is integral to testis formation, it affects processes that underlie testicular pathologies, including testicular cancer, and its potential to contribute to subfertility is beginning to be understood.

UR - http://www.sciencedirect.com/science/article/pii/S108495211500227X

U2 - 10.1016/j.semcdb.2015.10.029

DO - 10.1016/j.semcdb.2015.10.029

M3 - Review Article

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SP - 94

EP - 103

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

ER -